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08 May 2014, Volume 11 Issue 5 Previous Issue    Next Issue

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Protection of Bicyclol on Liver and Kidney Injury Induced by the Combination Therapy of Cisplatin and Gemcitabine in Tumor-bearing Mice ZHANG You-wen, WEI Huai-ling, BAO Xiu-qi, ZHANG Dan, SUN Hua* 2014, 11(5): 257-260.  Abstract ( 290 )   PDF (353KB) ( 135 )   ObjectiveTo determine the effect of bicyclol on cisplatin plus gemcitabine induced liver and kidney injury in tumor-bearing mice. MethodsC57/BL mice implanted with Lewis lung tumors for 6 days were treated with cisplatin References | Related Articles | Metrics

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Research of Extraction and Separation Technology and Anti-allergic Effect about Forgesin HU Han-wen, XU Xin-gang, ZHANG Xue-shun, SUN Rong 2014, 11(5): 261-263.  Abstract ( 239 )   PDF (422KB) ( 159 )   ObjectiveTo explore purification conditions of fargesin in Magnolia and conduct its experimental study of anti-allergic effect. MethodsThe structure of monomer composition from Magnolia was analyzed and identified. The effects on the experiments of anti-permeability strengthening of allergenic capillary vessels and passive anaphylaxis of the skin on mice from the monomer composition were explored. ResultsThe monomer composition was confirmed to be fargesin by UV, IR, MS and 13C-NMR. And it was considered to be effective to the effects on the experiments of anti-permeability strengthening of allergenic capillary vessels and passive anaphylaxis of the skin on mice. ConclusionFargesin, as one of the most effective components, presents a certain dose-efficacy relationship in the terms of the effects on the experiments of anti-permeability strengthening of allergenic capillary vessels and passive anaphylaxis of the skin on mice. References | Related Articles | Metrics

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Effect of Tannin Part of Tibetan Medicine Phyllanthus Emblica on the Migration and Invasion of HT1080 Cells ZHAO Hai-juan, GONG Man, CHANG Qing, YOU Yun, ZHANG Lan-zhen 2014, 11(5): 264-267.  Abstract ( 187 )   PDF (698KB) ( 227 )   Objective To investigate the effect of tannin part of Tibetan medicine Phyllanthus emblica on the migration and invasion of human fibrosarcoma cells HT1080. Methods MTT assay was performed to detect the inhibitory effect of tannin part of Phyllanthus emblica of different concentrations on proliferation of HT1080 cells. Wound-healing scrape assay and Transwell invasion assay were performed to assess the effect of tannin part on the migration and invasive properties of HT1080 in vitro. Results Tannin part of Phyllanthus emblica significantly inhibited the proliferation of HT1080 cells after 48 hours treatment, the median inhibitory concentration(IC50) was 0.174g·L-1. Compared with the control group, tannin part of emblica group of 0.1g·L-1 concentration significantly reduced the migration areas of HT1080 cells. The number of invasive transmembrane cells was decreased significantly in 0.025g·L-1 tannin part group. Conclusion Tannin part of Phyllanthus emblica could inhibit migration and invasion of human fibrosarcoma cells in vitro. References | Related Articles | Metrics

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Study on Extraction Process and Alcohol Precipitation of Jingshuning Granules JIAO Yu, WANG Bing-e, HUANG De-hong, WAN Hong, WANG Hong-jun, LI Qing, HU Si-rong 2014, 11(5): 268-270.  Abstract ( 208 )   PDF (435KB) ( 103 )   Objective To optimize the process of extraction and alcohol precipitation of Jingshuning Granules. Methods Using orthogonal test, the main influence factors of extraction and alcohol precipitation were investigated. Water volume, extraction time and times were inspected, with the metastasis rate of paeoniflorin and extract yield as influencing factors. The content of paeoniflorin and dry extract yield were used as index to study the relative density of concentrated liquid, alcohol concentration and time. Results The optimized extraction process was to add 10 times amount of water, extract for 3 times, 2 hours each time.The best process of alcohol precipitation was that the relative density of concentrated liquid was 1.12, alcohol concentration was 60%, and alcohol precipitation time was 24 hours. Conclusion The optimized technology of extraction and alcohol precipitation was reasonable, stable and reliable. It is suitable for industrial production. References | Related Articles | Metrics

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Determination of Six Kinds of Aconitum Alkaloids in Aconitum Carmichaeli and Its Samples by HPLC LUAN Yong-fu, SUN Rong 2014, 11(5): 271-274.  Abstract ( 261 )   PDF (447KB) ( 448 )   ObjectiveTo establish a HPLC method for the determination of six kinds of Aconitum alkaloids in Aconitum carmichaeli and its samples. MethodsA C18 column was used, and acetonitrile- tetrahydrofuran(25:15) as the mobile phase A, 0.1mol·L-1 NH4AC solution as the mobile phase B, gradient elute with a flow rate of 1.0mL·min-1 and a detection wavelength of 235nm. ResultsThe six kinds of Aconitum alkaloids were separated, and the calibration curves of them were in good linearity over the certain range respectively. ConclusionThis method is simple and accurate. It can be used in the identification and quality control of A. carmichaeli. References | Related Articles | Metrics

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Analysis of Drugs Approved by FDA in Recent Years REN Yu, YANG Yue 2014, 11(5): 275-280.  Abstract ( 379 )   PDF (617KB) ( 631 )   ObjectiveTo analyze drugs approved by FDA in recent years, and provide references for developing and approving drugs in China. MethodsThis article analyzes the number, review timeline and therapeutic area of drugs approved in America by literature. Resultsand ConclusionThe number of drugs approved by FDA has increased recently, the review timeline is shortened, and they have improved their focus on orphan drug, pediatric drug, cancer area, neurological and psychiatric disease and so on. Our country can refer to the drugs FDA has approved, and improve the policies of drugs approving to facilitate the development of new drugs and generic drugs. References | Related Articles | Metrics

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Research on Mode Selection of Adverse Drug Reaction Injury Relief System by Weighted TOPSIS CHEN Yong-fa, XIN Ying 2014, 11(5): 281-284.  Abstract ( 238 )   PDF (613KB) ( 134 )   This article makes evaluation and selection of ADR injury relief modes which were discussed based on stakeholder theory and a survey by weighted TOPSIS multi-objective decision-making method, in order to provide recommendations for the establishment of ADR relief system. According to the results, fund-insurance linkage mode ranked the highest, followed by insurance mode and the fund mode. Therefore fund-insurance linkage mode was recommended to establish ADR relief system. References | Related Articles | Metrics

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TIAN Ke-ren1 GAO Jing2 MIU Jian3 WAN Kai-hua2 YU Chao2 ZHOU Juan2 XU Jin2 LI Sui2 2014, 11(5): 285-287.  Abstract ( 269 )   PDF (597KB) ( 178 )   Objective To understand and analyze status of adverse drug reaction(ADR) monitoring and inspection system for drug manufacturers. Methods Using stratified sampling method, 88 drugmanufacturers of 12 cities in Jiangxi province were extracted. We designed the ADR monitoring and reporting questionaires, and 88 effective questionnaires were returned. Results 88 drug manufacturers all have set up branches of ADR monitoring, and established a ADR-monitoring system. 67.25% manufacturers have full-time personnel, 18.18% manufacturers have reported directly through the network(a total of 65 cases), 48.86% manufacturers have carried regular pooled analytical work, 39.77% have worked on risk assessment, 48.86% manufacturers have written Periodic Safety Update Report(PSUR). Conclusion The work system of ADR monitoring for drug manufacturers has been perfected more and more, but the monitoring has not been widely spreaded, the effect of ADR monitoring is low. References | Related Articles | Metrics

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Literature Analysis of 35 Cases of Adverse Drug Reaction/Event Induced by Brucea Javanica for Topical Use GAN Ge, BIAN Rong-rong, SUN Jun 2014, 11(5): 288-290.  Abstract ( 240 )   PDF (571KB) ( 155 )   ObjectiveTo investigate the epidemiological characteristics of adverse drug reactions/event(ADR/ADE）induced by Brucea javanica. MethodsWith retrospective case study, analyzed 35 cases of ADR/ADE induced by Brucea javanica, which were searched from Chinese Journal Full-text Database between1958 and 2012. Results29 cases were acute allergy, including 20 allergic shock cases. Acute allergy usually occurred in 60 min after drug treatment, 18 cases occurred in 5 min after drug treatment. 4 cases were acute eye injury, manifested as eye pain, foreign body sensation, photophobia, blurred vision and severe vision loss. Other clinical manifestations were epidermolytic necrotizing dermatitis(1case) and right lower limb swelling(1 case). ConclusionBrucea javanica for topical use may induce serious ADR/ADE, which should be strengthened to observe and evaluate. References | Related Articles | Metrics

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Analysis of 4120 Reports of Adverse Drug Reaction Induced by Antitumor Drugs ZHENG Dong-yan, ZHAI Shu-yue, CUI Ran, LU Chang-fei 2014, 11(5): 291-294.  Abstract ( 275 )   PDF (620KB) ( 281 )   ObjectiveTo study regularities and characteristics of adverse drug reaction(ADR) induced by the antitumor drugs, analyze characteristics and influence factors of the bone marrow depression induced by antitumor drugs, and provide references for the clinical rational use of antitumor drugs, so as to prevent or reduce the ADRs. Methods4 120 reports of ADR induced by antitumor drugs in 2012 in our province were retrospectively analyzed. ResultsIn the 4 120 ADR reports of antitumor drugs, the number of ADR report was higher in platinum, plant sources of antitumor drug and its derivatives, other antitumor drugs and adjuvant therapy drugs. The digestive system was the most adverse reactions involving system, followed by the blood system, skin and its accessory. Damage in the blood system was mainly caused by bone marrow suppression. In the bone marrow suppression induced by antitumor drugs, cisplatin resulted in the highest incidence of bone marrow suppression, followed by docetaxel, gemcitabine, paclitaxel, etc. ConclusionWe should strengthen the monitoring of adverse events of antitumor drugs, pay more attention to the damage caused by bone marrow suppression, promote rational drug use, and prevent or reduce the incidence of ADRs. References | Related Articles | Metrics

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Comparative Analysis of Serious Adverse Reactions Caused by Docetaxel and Paclitaxel YANG Yue-ming, WANG Yu-xin WANG Li-gang 2014, 11(5): 295-296.  Abstract ( 373 )   PDF (578KB) ( 607 )   ObjectiveTo investigate the characteristics of serious adverse reactions caused by docetaxel and paclitaxel in order to provide reference for safe drug use in clinical practice. MethodsReports of serious adverse reactions were selected from reports caused by docetaxel and paclitaxel from Liaoning Adverse Drug Reaction Monitoring Center from January 2004 to January 2013. The clinical manifestations of serious adverse reactions and outcomes between the two drugs were compared. ResultsA total of 31 reports were entered, involving 31 patients and 33 cases of adverse reactions. Thirty one patients comprised 9 male and 22 female with average age of 53 years(31~76 years). Seventeen cases of serious adverse reactions caused by paclitaxel included anaphylactic shock(70.59%), anaphylaxis(11.76%), leucopenia(11.76%) and marrow depression(5.88%). Sixteen cases of serious adverse reactions caused by docetaxel included anaphylaxis(31.25%), marrow depression(18.75%), leucopenia(18.75%), diarrhea(6.25%), anaphylactic shock(6.25%), gastrointestinal bleeding(6.25%), back pain(6.25%) and dyspnea(6.25%). After drugs were stopped and symptomatic treatments were given, all the patients were cured. ConclusionDocetaxel and paclitaxel have some different clinical manifestations in serious anaphylaxis, the ratio of anaphylactic shock caused by paclitaxel was highter than by docetaxel, so guidance of medication and monitoring should be strengthened. References | Related Articles | Metrics

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Literature Analysis of 86 Cases of Adverse Reaction /Event Caused by Allopurinol Tablet TAN Li-li 2014, 11(5): 297-300.  Abstract ( 268 )   PDF (670KB) ( 203 )   ObjectiveTo explore the clinical features, correlation rules and mechanism of ADR/ADE caused by allopurinol tablet, and to provide a reference for clinical rational use of drugs. MethodsRetrieving CBM Database, CNKI and Chinese Periodical Full-text Database, literatures on ADR/ADE caused by allopurinol tablet during 1994~2013 were statistically analyzed. Results86 ADR/ADE cases were enrolled. The number of male patients was more than female; the 61~70 years old patients were with the highest incidence; the majority of ADR/ADE cases broke out within 1 month after medication(79 cases,91.86%); the adverse reactions involved many systems and organs, and there were some new and severe ADR/ADE cases, even some were dead; the main manifestation of ADR/ADE was skin system References | Related Articles | Metrics

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Literature Analysis of 33 Cases of Thrombocytopenia Induced by Linezolid HUANG Li, LU Xiang-hong, LUO Jia 2014, 11(5): 301-303.  Abstract ( 286 )   PDF (619KB) ( 306 )   Objective To study the features of thrombocytopenia induced by linezolid through literature analysis and provide reference for clinical rational use of linezolid. Methods To collect literatures from 2001 to 2012 reported in China National Knowledge Infrastructure(CNKI) and VIP medical journal database with linezolid,thrombocytopenia and ADR as key words,and to analyze statistically the 33 ADR cases involved in 19 articles of linezolid inducing thrombocytopenia. Results Twenty five cases were male, 8 cases were female, 23 cases were more than 60 years old. The high-risk factors of thrombocytopenia were advanced age,low baseline platelet count(≤200×109·L-1) and long course of treatment. Most cases returned to normal after drug withdrawal and corresponding treatments in 7~14 days. Conclusion In order to detect earlier and deal correctly,we should pay more attention to the ADR of linezolid inducing thrombocytopenia.It needs to observe closely and monitor blood routine examination during application. References | Related Articles | Metrics

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Analysis of 45 Cases of Adverse Drug Reaction Induced by Alprostadil HUANG Qian, ZHANG Zheng, LIU Li-hong 2014, 11(5): 304-305.  Abstract ( 248 )   PDF (602KB) ( 249 )   ObjectiveTo analyze the adverse drug reaction(ADR) caused by alprostadil in our hospital and to provide reference to its rational use. MethodsThe cases of ADR by alprostadil reported in our hospital from 2008 to 2012 were collected. A statistical analysis was conducted based on gender, age, clinical manifestation, rescue strategies and prognosis of the ADR. ResultsFor 45 cases collected, the ages of patients were mostly over 30, the primary ADRs related organs or systems were peripheral vascular system, skin and central nervous system. The main clinical manifestations were phlebitis, rash, dizzy and headache, most appeared 0~3 days after dosing. ConclusionThe monitoring for adverse reactions of alprostadil should be strengthened. Early prevention can reduce the incidence of adverse reactions. References | Related Articles | Metrics

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Application of Information System for Drug Safety Monitoring of Intravenous Drip in Outpatient Department CAO Xiu-Qin, SONG Jin-Bo 2014, 11(5): 306-308.  Abstract ( 301 )   PDF (663KB) ( 180 )   ObjectiveTo control the factors affecting the safety of intravenous drip infusion, and normalize the ADR report. MethodsAutomatically validate the factors influencing main steps of drug safety including dosage, administration route and drug compatibility through program modification. Offer the reminding of ADR report and provide more complete information. Achive the closed-loop management of outpatient intravenous drug use when combined with transforming processes. Resultsand ConclusionThis system and process can reduce the incidence of mistakes in the administration of outpatient intravenous drug safety and improve the quality of ADR report. References | Related Articles | Metrics

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Study on Solvent Compatibility of Shuxuening Injection WANG Yan-chun, LI Xu-dong, LIU Ying, FENG Ying 2014, 11(5): 309-311.  Abstract ( 431 )   PDF (579KB) ( 343 )   ObjectiveTo study the safety of Shuxuening injection using different solvent. Methods5% glucose in water as solvent and 0.9% NaCl in water as solvent of Shuxuening injection were studied, and the results of 0.9% NaCl in water were analyzed retrospectively in one of our supervised hospital. ResultsThe stability, pH and insoluble substance of Shuxuening injection using 0.9% NaCl in water as solvent were in line with the Chinese Pharmacopoeia(2010 edition), and none adverse reactions were detected. ConclusionAlthough there were no instructions of Shuxuening injection concerning 0.9% NaCl in water as solvent, but our research results could certify the safety and stability of 0.9% NaCl in water as solvent of Shuxuening injection. We suggested that the instruction of Shuxuening injection could be changed for reasonable administration to patients. References | Related Articles | Metrics