Abstract: ObjectiveTo investigate the characteristics of serious adverse reactions caused by docetaxel and paclitaxel in order to provide reference for safe drug use in clinical practice. MethodsReports of serious adverse reactions were selected from reports caused by docetaxel and paclitaxel from Liaoning Adverse Drug Reaction Monitoring Center from January 2004 to January 2013. The clinical manifestations of serious adverse reactions and outcomes between the two drugs were compared. ResultsA total of 31 reports were entered, involving 31 patients and 33 cases of adverse reactions. Thirty one patients comprised 9 male and 22 female with average age of 53 years(31~76 years). Seventeen cases of serious adverse reactions caused by paclitaxel included anaphylactic shock(70.59%), anaphylaxis(11.76%), leucopenia(11.76%) and marrow depression(5.88%). Sixteen cases of serious adverse reactions caused by docetaxel included anaphylaxis(31.25%), marrow depression(18.75%), leucopenia(18.75%), diarrhea(6.25%), anaphylactic shock(6.25%), gastrointestinal bleeding(6.25%), back pain(6.25%) and dyspnea(6.25%). After drugs were stopped and symptomatic treatments were given, all the patients were cured. ConclusionDocetaxel and paclitaxel have some different clinical manifestations in serious anaphylaxis, the ratio of anaphylactic shock caused by paclitaxel was highter than by docetaxel, so guidance of medication and monitoring should be strengthened.

Key words: paclitaxel, docetaxel, serious adverse reaction