Abstract: ObjectiveTo study regularities and characteristics of adverse drug reaction(ADR) induced by the antitumor drugs, analyze characteristics and influence factors of the bone marrow depression induced by antitumor drugs, and provide references for the clinical rational use of antitumor drugs, so as to prevent or reduce the ADRs. Methods4 120 reports of ADR induced by antitumor drugs in 2012 in our province were retrospectively analyzed. ResultsIn the 4 120 ADR reports of antitumor drugs, the number of ADR report was higher in platinum, plant sources of antitumor drug and its derivatives, other antitumor drugs and adjuvant therapy drugs. The digestive system was the most adverse reactions involving system, followed by the blood system, skin and its accessory. Damage in the blood system was mainly caused by bone marrow suppression. In the bone marrow suppression induced by antitumor drugs, cisplatin resulted in the highest incidence of bone marrow suppression, followed by docetaxel, gemcitabine, paclitaxel, etc. ConclusionWe should strengthen the monitoring of adverse events of antitumor drugs, pay more attention to the damage caused by bone marrow suppression, promote rational drug use, and prevent or reduce the incidence of ADRs.

Key words: antitumor drugs, adverse reaction, bone marrow suppression