Simple febrile seizures within 30 days of vaccination with the measles, mumps and rubella combined attenuated live vaccine in U-12 children in the real world

doi:10.19803/j.1672-8629.20240208

Abstract

Abstract: Objective To analyze the way in which simple febrile seizures (SFS) occur within 30 days of vaccination with the measles, mumps and rubella combined attenuated live vaccine (MMR) in children under 12 in Gansu Province using the real-world data. Methods Cases diagnosed with “febrile seizures” were screened out from the electronic medical records of Gansu Province between 2021 to 2023. The patient identity information was used to match the vaccination information in Gansu Province Immunization Information System. An observational epidemiological approach was employed to analyze the characteristics of SFS after MMR. Results A total of 10 614 patients with SFS were included. The overall incidence of SFS in children under 12 was 92.42 per 100 000, with the highest incidence observed among children ages 12 to 24 months (297.67 per 100 000). The risk of SFS in males was higher than in females (RR= 1.61, P < 0.001). The risk of SFS increased within 30 days of MMR vaccination (RR= 2.66, P < 0.001). The incidence after the first dose (27.98 per 100 000) was higher than after the second dose (24.13 per 100 000). In children ages 12 to 24 months, the risk of SFS within 6 to 14 days after the first dose of MMR vaccine was higher than among those under 12 months, aged 25 months to 6 years (RR=4.06 and 2.64, respectively, both P < 0.001). Conclusion The risk of SFS within 6 to 14 days of MMR vaccination increases in children ages 12 to 24 months, so this age group is the most vulnerable. High-risk populations should be closely monitored.

Key words: simple febrile seizures, measles, mumps and rubella combined attenuated live vaccine, children, vaccination, adverse reactions

CLC Number:

R978
R994.11

LIU Yan, AN Jing, JIAO Yongzhuo, LIANG Xuefeng, ZHANG Xiaoshu. Simple febrile seizures within 30 days of vaccination with the measles, mumps and rubella combined attenuated live vaccine in U-12 children in the real world[J]. Chinese Journal of Pharmacovigilance, 2024, 21(7): 805-810.

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https://zgywjj.magtechjournal.com/EN/Y2024/V21/I7/805

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