Abstract: Objective To explore such adverse reactions as anaphylactic symptoms caused by polyethylene glycol electrolyte powder, and to provide reference for the study of the mechanism underlying allergies caused by polyethylene glycol electrolyte powder. Methods Two cases of allergic reactions in children of the same father and mother caused by polyethylene glycol electrolyte powder were analyzed. Tips for medication were given by searching the literature for similar cases. Results Two children developed allergic symptoms after taking polyethylene glycol electrolyte powder. Symptoms gradually disappeared after discontinuing the drug and giving anti-allergy treatment. Analysis of the causes and review of related literature showed that the adverse reaction in these two children were likely related to polyethylene glycol electrolyte powder. Conclusion Allergic reactions caused by compound polyethylene glycol electrolyte powder reported in this paper tend to run in families, which may be associated with specific gene loci, so the association with gene molecular biology needs to be investigated. There is a risk of allergic reactions when cotrimoxazole polyethylene glycol powder is used for intestinal cleansing prior to colonoscopy operations. Patients need to be reminded to avoid self-administration and to discontinue medication and seek immediate medical attention in case of discomfort.

Key words: polyethylene glycol electrolyte powder, polyethylene glycols, adverse drug reactions, allergy-like symptoms, children