172 Cases of Adverse Drug Reactions Induced by Antineoplastic Drugs

doi:10.19803/j.1672-8629.20240497

Abstract

Abstract: Objective To analyze the clinical characteristics and patterns of adverse drug reactions (ADR) induced by antineoplastic drugs in our hospital in order to provide a reference for the safe and rational use of antineoplastic drugs. Methods ADR reports related to antineoplastic drugs and submitted by our hospital to the active monitoring and reporting system of the National Adverse Drug Reaction Monitoring Center between 2019 and 2023 were retrospectively analyzed. Results A total of 172 ADR reports of antineoplastic drugs were retrieved, and the percentage of males and females involved in these reports was 51.16% and 48.84% respectively. Patients aged 60 or older accounted for 54.65%. Among the primary diseases mentioned in the reports, malignant tumors of the lung and stomach were dominating, with 21 cases（12.21%）each. The most common route of administration mentioned in these ADR reports was intravenous infusion (62.79%) while the most common antineoplastic drugs found in these ADR reports were small molecule targeted drugs (31.98%). The prevalent ADR of antineoplastic drugs included blood system damage (24.45%), systemic damage (17.47%) , hepatobiliary system damage (16.59%), bone marrow suppression, abnormal liver function, and chills/shivering are common clinical manifestations. Among new antineoplastic drugs, the top three ones responsible were rituximab in 21 cases (19.63%), sintilimab in 15 cases (14.02%), and bevacizumab and camrelizumab in 8 cases (7.48%). There were 95 cases of common ADR and 77 cases of severe ADR, with the majority of patients improved. Conclusion Appropriate anti-tumor treatment regimens should be provided based on the characteristics of patients. Related ADR should be monitored to ensure medication safety.

Key words: Antineoplastic Drugs, New Antineoplastic Drugs, Small Molecule Targeted Drugs, Adverse Drug Reactions, Medication Safety, Pharmacovigilance

CLC Number:

LIANG Jie. 172 Cases of Adverse Drug Reactions Induced by Antineoplastic Drugs[J]. Chinese Journal of Pharmacovigilance, 2025, 22(8): 928-932.

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https://zgywjj.magtechjournal.com/EN/Y2025/V22/I8/928

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