Effect of Sugammadex on Recovery of Patients after Laparoscopic Total Pelvic Floor Reconstruction

doi:10.19803/j.1672-8629.20250342

Abstract

Abstract: Objective To evaluate the role of sugammadex in neuromuscular blockade (NMB) recovery and safety in patients undergoing laparoscopic total pelvic floor reconstruction (LTPFR) surgery. Methods A single-center retrospective cohort study was conducted. One hundred and one patients undergoing LTPFR were enrolled and divided into three groups based on their postoperative antagonism of NMB, including the sugammadex group (S-group, n=20), neostigmine group (N-group, n=33), and no-antagonism group (C-group, n=48). The primary outcome was the time to extubation, and the secondary outcomes included the length of stay at the post-anesthesia care unit (PACU) and the incidence of adverse events during recovery from general anesthesia. Such statistical methods as one-way ANOVA, χ² test, or Fisher’s exact test were used to make a comparison between the groups with the significance level set at α=0.05. Results The time to extubation in S-group was significantly shorter than that of N-group and C-group [(3.1±1.5) min vs (6.9±2.3) min and (5.7±1.2) min, P<0.001)]. The stay at the PACU in S-group was significantly shorter than that of N-group [(29.8±10.1) min vs (36.7±9.5) min, P<0.017]. The incidence of adverse events during recovery in S-group was significantly lower than that of N-group (15% vs 48.5%,P<0.001). The adverse events primarily manifested as nausea and cardiovascular events such as hypertension and tachycardia in N-group. Conclusion Sugammadex can rapidly reverse rocuronium-induced NMB, significantly shorten the time to extubation and PACU stay in patients undergoing LTPFR, and reduce the incidence of adverse events during recovery. Its clinical applications conform to the principles of Enhanced Recovery After Surgery (ERAS).

Key words: Sugammadex, Laparoscopes, Total Pelvic Floor Reconstruction, Neuromuscular Blocking Agents, Treatment Outcome, Adverse Drug Reactions

CLC Number:

R971

LI Mingying, ZHANG Xiaoxia, SUN Xiaoli, ZHAO Yan, HE Miao, LI Yanling, DUAN Wei, YANG Ou. Effect of Sugammadex on Recovery of Patients after Laparoscopic Total Pelvic Floor Reconstruction[J]. Chinese Journal of Pharmacovigilance, 2025, 22(8): 896-901.

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URL: https://zgywjj.magtechjournal.com/EN/10.19803/j.1672-8629.20250342

https://zgywjj.magtechjournal.com/EN/Y2025/V22/I8/896

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