Abstract: Objective To review of research status on seven common conditional fungi that are prone to adverse reactions, analyze their toxic components, and propose corresponding safety utilization suggestions, so as to provide reference for their resource development and sustainable utilization. Methods By reviewing domestic and foreign literature and relevant books, the current research status, efficacy, toxic components, adverse reactions, and other aspects of seven common fungi that are prone to adverse reactions were summarized. Results Seven types of common fungi that are prone to adverse reactions, including Boletus、Bulgaria inguinans、Auricularia auricula、Amanita、Gymnopilus spectabilis、Coprinus comatus、Paxillus involutus contain complex types of toxic components, including peptides, alkaloids, amino acids, oligoisoprene compounds, etc, which may cause adverse reactions such as neurotoxicity, photosensitivity, gastrointestinal irritation, disulfiram-like reaction, hemolytic poisoning, etc. It is important to pay attention to them.. At the same time, these fungi are rich in various bioactive components with significant pharmacological activity, and some toxic components have the potential to be developed into anti-inflammatory, analgesic, antidepressant drugs, etc, which is worthy of further research and rational utilization. Conclusion Fungi that are prone to adverse reactions are also important resources for medicinal fungi, with great development value. Currently, many studies on fungi that are prone to adverse reactions focus on pharmacological and toxicological effects. Their virulence factors and toxic mechanisms are not yet clear, and further in-depth research is needed to provide theoretical basis for their development and utilization.

Key words: conditional fungi, neurotoxicity, photosensitivity, gastrointestinal irritation, disulfiram-like reaction, adverse reactions, toxic components, secure applications