Chinese Journal of Pharmacovigilance ›› 2014, Vol. 11 ›› Issue (5): 261-263.

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Research of Extraction and Separation Technology and Anti-allergic Effect about Forgesin

HU Han-wen1, XU Xin-gang2, ZHANG Xue-shun3, *, SUN Rong2   

  1. 1Shandong University of Traditional Chinese Medicine, Shandong Ji'nan 250355, China;
    2Shandong Academy of Chinese Medicine, Shandong Ji'nan 250014, China;
    3First Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong Ji'nan 250011, China
  • Received:2016-02-03 Revised:2016-02-03 Online:2014-05-08 Published:2016-03-02

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Abstract: ObjectiveTo explore purification conditions of fargesin in Magnolia and conduct its experimental study of anti-allergic effect. MethodsThe structure of monomer composition from Magnolia was analyzed and identified. The effects on the experiments of anti-permeability strengthening of allergenic capillary vessels and passive anaphylaxis of the skin on mice from the monomer composition were explored. ResultsThe monomer composition was confirmed to be fargesin by UV, IR, MS and 13C-NMR. And it was considered to be effective to the effects on the experiments of anti-permeability strengthening of allergenic capillary vessels and passive anaphylaxis of the skin on mice. ConclusionFargesin, as one of the most effective components, presents a certain dose-efficacy relationship in the terms of the effects on the experiments of anti-permeability strengthening of allergenic capillary vessels and passive anaphylaxis of the skin on mice.

Key words: fargesin, effective component, anti-allergic effect

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