Chinese Journal of Pharmacovigilance ›› 2014, Vol. 11 ›› Issue (5): 309-311.

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Study on Solvent Compatibility of Shuxuening Injection

WANG Yan-chun1, LI Xu-dong1, LIU Ying2, FENG Ying1   

  1. 1Fushun Center for ADR Monitoring, Liaoning Fushun 113006, China;
    2Dalian Center for ADR Monitoring, Liaoning Dalian 113006, China
  • Received:2016-02-03 Revised:2016-02-03 Online:2014-05-08 Published:2016-03-02

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Abstract: ObjectiveTo study the safety of Shuxuening injection using different solvent. Methods5% glucose in water as solvent and 0.9% NaCl in water as solvent of Shuxuening injection were studied, and the results of 0.9% NaCl in water were analyzed retrospectively in one of our supervised hospital. ResultsThe stability, pH and insoluble substance of Shuxuening injection using 0.9% NaCl in water as solvent were in line with the Chinese Pharmacopoeia(2010 edition), and none adverse reactions were detected. ConclusionAlthough there were no instructions of Shuxuening injection concerning 0.9% NaCl in water as solvent, but our research results could certify the safety and stability of 0.9% NaCl in water as solvent of Shuxuening injection. We suggested that the instruction of Shuxuening injection could be changed for reasonable administration to patients.

Key words: Shuxuening injection, solvent, stability, insoluble particles, pH, clinical research

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