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08 October 2010, Volume 7 Issue 10 Previous Issue    Next Issue

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The Impact of Xu Duan Tong Luo Pian on Nerve Conduction Velocity of Experimental Diabetic Rats YANG Xiao-hui ,DENG Yuan-yuan 2010, 7(10): 577-578.  Abstract ( 194 )   PDF (341KB) ( 204 )   Objective To observe the impact of Xu Duan Tong Luo Pian(XDTLP) on nerve conduction velocity(NCV) of experimental diabetic peripheral neuropathy(DPN) rats. Methods Diabetic rats were induced by STZ celiac injection. Then, the rats which successfully became diabetic model were divided into diabetic model group. Methycobal was given by 0.25mg/kg·d, XDTLP was given by3.2、6.3、12.6g/kg·d herb according to low, middle and high dose, which lasted 8 weeks. Results After treatment with XDTLP for8 weeks, NCV increased greatly. Conclusion The experiment showed that XDTLP can significantly improve the nerve conductive velocity in rats with DPN. References | Related Articles | Metrics

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Experimental Comparison Study on Mice's Acute Toxicity of Different Composition in Cortex Periplocae SUN Rong, BAO Zhi-ye, HUANG Wei ,LV Li-li, ZHANG Zuo-ping ,REN Hai-yong 2010, 7(10): 579-584.  Abstract ( 236 )   PDF (522KB) ( 223 )   Objective To compare the acute toxicity of different components in Cortex Periplocae on mice which is all components、water extraction components and alcohol extraction components, make an observation and evaluation of acute toxicity to Cortex Periplocae herbs in order to provide a basis for safe and reasonable medication in clinical. Methods Respectively prepare the all components、water extraction components and alcohol extraction components, and compare the acute toxicity of different components in Cortex Periplocae on mice in accordance with classical acute toxicity test methods, and the experimental datas are calculated LD50 with the Bliss method and MTD method, with the continuous administration and observation for 14 days. Results the all components in Cortex Periplocae is unable to make LD50, MTD Results calculated in accordance with crude drug content is respectively 16.0g·kg-1·d-1,which is equal to 186.6 times of 70kg people's daily dried medicinal herb expenses. The LD50 of water extraction components and alcohol extraction components in Cortex Periplocae are 93.578g·kg-1·d-1 and the 95% confidence limit is 89.149～98.484g·kg-1·d-1 which is equal to1 091.8 times of 70kg people's daily dried medicinal herb expenses and 61.388g·kg-1·d-1 and the 95% confidence limit is 57.466～65.521g·kg-1·d-1 which is equal to 716.2 times of 70kg people's daily dried medicinal herb expenses. The main toxical symptoms and signs are the convulsions, tetraplegia, diarrhoea and the respiratory depression, the deaths mainly occurred in less than 48 hours used by the all components、water extraction components and alcohol extraction components. Conclusion The acute toxicity of different components in Cortex Periplocae on mice is: alcohol extract>water extract>all-components. References | Related Articles | Metrics

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Antitumor Activities of Huanglianjiedu Decoction in Vivo and in Vitro SUN Jian, YU You-hua ,ZHANG Zheng-yao ,ZHANG Yang, ZHOU Qiu-li 2010, 7(10): 585-589.  Abstract ( 192 )   PDF (433KB) ( 198 )   Objective To study the antitumor activities of Huanglianjiedu Decoction(HLJDT) in vivo and in vitro. Methods Antitumor activities were tested in mice with experimental tumor S180 and MFC in vivo, thymus index, spleen index, tumor inhibitory rate were evaluated. Cell proliferation was assayed by using methyl thiazolyl tetrazolium (MTT) method in vitro. S180, MFC, SGC -7901 and SMMC -7721 cancer cells were incubated in culture media containing HLJDT. Results HLJDT showeda Antitumor activities on S180 and MFC in vivo. All of the HLJDT in different dosage groups could highly inhibit the proliferation of 4 cancer cells. Conclusion The HLJDT could inhibit the tumor S180, MFC in mice, the drug has obvious anticancer effects against S180, MFC, SGC -7901 and SMMC7721. References | Related Articles | Metrics

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Report on Vaccine-induced Immunity of HIV-exposed Infants GUI Xiu-zhi, WENG Yu-qiu, MO Sheng ,QIU Hui 2010, 7(10): 588-591.  Abstract ( 175 )   PDF (397KB) ( 150 )   The purpose is to investigate immune tolerance and the efficacy of hepatitis B vaccine and BCG immunization of infants on the prevention of mother to child transmission(PMTCT) programs, in order to provide the basis for corresponding vaccination policy. We provide PMTCT service to HIV -positive mothers and define infants of HIV-positive mothers as experimental group(EG), while infants beard by HIV-negative mothers as comparative group (CG). The two groups were vaccinated regularly and had PPD tests and anti-HBs level tests. In consequence, the HIV prevalence in infants born to mothers on the PMTCT programs is substantially lower than infants not in the program.The PPD-positive rates of the both groups are above 90%, and the mean content of anti-HBs for EG and CG are 296.83~3.10mIU/mL and 354.30~2.37mIU/mL respectively. In Conclusion , the efficacy of hepatitis B and BCG vaccine immunization of infants born to HIV-positive mothers is similar to normal infants. References | Related Articles | Metrics

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Application of Qualitative Research Methods in the Study of Adverse Drug Reaction(2): An Example of the Interview FEI Yu-tong, CAO Hui-juan ,SUN Ying ,LIU Jian-ping 2010, 7(10): 592-594.  Abstract ( 194 )   PDF (400KB) ( 161 )   This essay introduce the implementation of an interview, the data analysis from the interview, and reporting by giving an example in adverse drug reaction(ADR). The purpose is to help with researchers to use qualitative method to investigate ADR. References | Related Articles | Metrics

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Exploration of the Methodology in the Evaluation of Safety of Non-pharmaceutical Therapy CAO Hui –juan, LI Xun ,LIU Jian –ping 2010, 7(10): 595-597.  Abstract ( 170 )   PDF (412KB) ( 192 )   Non -pharmaceutical therapies play a major role in traditional medicine. However, the reporting of their safety is not paid enough attention. This paper focused on safety issues of non-pharmaceutical therapies, introduced several Methods including randomized clinical trials, cohort study, case report, questionnaire, and qualitative method, respectively. Based on findings of above research methods, we introduced method of research synthesis so to provide references for clinical researches in non-pharmaceutical therapies. References | Related Articles | Metrics

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The Application of Meta-Analysis Method in the Case-control Study of Adverse Drug Reaction LUO Hui ,LIU Jian-ping 2010, 7(10): 598-600.  Abstract ( 203 )   PDF (459KB) ( 440 )   There is distinctive advantage in the research of adverse drug reaction using by case -control study. The qualitative statistics analysis of case-control study by using Meta-analysis method can improve the grade of the evidence in research, in order to clarify the causality between drugs and their adverse reaction. This paper had demonstrated the application of Meta-Analysis method in the case-control study of adverse drug reaction. References | Related Articles | Metrics

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The Essentiality of Medical Device Adverse Event Monitoring to the Medical Device Anew Registration DONG Fang 2010, 7(10): 601-602.  Abstract ( 188 )   PDF (425KB) ( 266 )   Medical device adverse event monitoring and medical device anew registration are the two inseparable supervision section for before and after medical device launch. It is reaction each other and which is the inner request of risk management in its all life cycle. Medical device adverse event monitoring is very important to anew registration, which its aim to detect the potential risk of post-marketing and replenish the data which couldn't sufficiency supplied during prophase registration. Through anew registration we will refer adverse event evaluation reports and strengthen the responsibility consciousness of enterprise. It can improve the safety of anew registration medicals and distinct every departmental duties. As the same time it can promote the work of medical device adverse event monitoring and raise the safety of medical device. Related Articles | Metrics

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Discussion on the Application of Risk Matrix Method for Drug Risk Assessment WU Chang –qing, ZHU Wen –tao 2010, 7(10): 603-604.  Abstract ( 201 )   PDF (526KB) ( 253 )   To discusses the risk matrix for risk management tools such as the introduction of risk assessment of adverse drug reaction(ADR) and their management of related issues. Give the suggestion that managing the risk of before and after durgs appearing on the market is good for ensuring the safety use of drug of patients. References | Related Articles | Metrics

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Discussion on the Establishment of Drug Relief Fund in China SUN Yun, LIU Yang 2010, 7(10): 605-606.  Abstract ( 188 )   PDF (488KB) ( 208 )   To discusses the victim how to get the effective and timely relief after the incident occured.Analysis our legislation and the implementation of such issues, learn from China's Taiwan region drug -induced sufferings relief system, and advance the system and strategy which tally with the national condition. References | Related Articles | Metrics

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Discuss on the Risk Control of Traditional Chinese Medicine WU Cheng-yun ,HUANG Wen-zhi, ZHENG Qing-ming ,ZHANG Li, ZHOU Ya-li ,ZHANG Cheng-xu 2010, 7(10): 607-610.  Abstract ( 209 )   PDF (548KB) ( 203 )   This essay based on analyzing the pertinent literature, unscrambling the correlative laws and regulations of drug administration in force, and combining the situation of Traditional Chinese Medicine(TCM), The influential factors of TCM safety were discussed; as for the organizations relative to TCM, the responsibility and obligation were determined to controlling the risks from TCM, how and take what measures to decrease the risks were stated as well. References | Related Articles | Metrics

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The Role of the Information Communication in Drug Risk Management CHEN Chong-ze 2010, 7(10): 611-612.  Abstract ( 177 )   PDF (485KB) ( 205 )   The importance of the information communication has already becomea drug risk administrator's common understanding. From analyzing the importance of the information communication and main obstacle of the information communication are started with, what effective realization and question that should be paid attention to the information communication is to sum up. References | Related Articles | Metrics

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The Status and Role of Modern Analytical Techniques in the Toxicology of Traditional Chinese Medicine SUN Rong ,ZHENG Li-na ,ZHU Lan-lan, YANG Qian 2010, 7(10): 613-616.  Abstract ( 195 )   PDF (567KB) ( 301 )   Objective To approach the status and roles of modern analytical techniques in researching for toxicology of Traditional Chinese Medicine. Methods Collect, and summarize domestic related literature of the last decade. Results Ultraviolet Spectrophotometry(UV), Atomic Absorption Spectrometry(AAS), Fluorescence Spectroscopy(FS), High Performance Liquid Chromatography(HPLC), Gas Chromatography(GC), High Performance Liquid Chromatogr-aphy-Mass Spectrometry(HPLC-MS), Gas Chromatography -Mass Spectrometry(GC-MS) and Molecular Biology Techniques ( MBT) are commonly used in toxicology of Traditional Chinese Medicine sdudies, in which HPLC, GC -MS, HPLC -MS are the most widely used. Conclusion Modern analytical techniques in the study of vivo process of Traditional Chin-ese Medicine plays an important role, mainly for the determination of the concentration of toxic substances in blood or liver, kidney and other important tissue; And with the developmentof modern analytical techniques and the improvement of the sensitivity of analytical instruments, they will promote the further development of toxicology of Traditional Chinese Medicine. With the establishment and discoveries of new theories and new technology of modern toxicology, modern analytical techniques will play an more important role in Toxicodynamics (TD) and Toxicokinetics(TK) studies of Traditional Chinese Medicine, and plays an irreplaceable effect. References | Related Articles | Metrics

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The Mechanism and Therapy Perspective of Erlotinib in Patients with Non-small Cell Lung Cancer ZHAO Yan, ZHANG Ru 2010, 7(10): 617-619.  Abstract ( 177 )   PDF (519KB) ( 253 )   By overviewing the mechanism ,clinical application and adverse drug reaction(ADR) of erlotinib, to indicate its perspective in the therapy of non-small cell lung cancer. References | Related Articles | Metrics

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Analysis of 154 Reports of Serious Drug Adverse Reaction Induced by Shuxuening Injection YANG De-ping 2010, 7(10): 620-622.  Abstract ( 246 )   PDF (654KB) ( 195 )   Objective In order to provide reference for clinical rational use of Shuxuening injection by analysis of 154 reports of serious drug adverse reaction induced by Shuxuening injection. Methods 154 reports of serious drug adverse reaction induced by Shuxuening injection were statistical analyzed from 2004 to 2009 in Qinghai Center for ADR monitoring. Results Serious adverse reactions were include skin damage and annex damage, systemic damage, central and peripheral nervous system damage, gastrointestinal system damage/respiratory damage and other accounted for 85.62%. Anaphylactic shock, dyspnean suffocating, laryngeal edema and other is the mainly serious adverse reactions, none of dieth and sequelae case. Conclusion We should enhance the rational use and monitoring of Shuxuening injection to avoid adverse reactions. References | Related Articles | Metrics

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Analysis of 170 Cases on Adverse Drug Reaction of Shenmai Injection LI Ying-ran, PAN Tai-xian 2010, 7(10): 623-625.  Abstract ( 256 )   PDF (639KB) ( 284 )   Objective To explore the general rule and the characteristics of adverse drug reaction(ADR) induced by Shenmai injection and to provide some references for clinical medicine and rational use of drug. Methods One part of the ADR reports were collected by Zhongshan People's Hospital of 2008 to 2009, another part of the reports were collected by national journals of 1994 to 2009. 170 ADR则eports were analyzed using retrospective study method. Results ADR appeared mostly in the 40 age group, and more in female. The onset of ADR was usually within the first 30 min during the infusion. and the clinical manifestations of ADR were various, of which the allergic reaction was the most common. Conclusion Doctors and pharmacists should pay more attention to the ADR of Shenmai injection for the Immediate allergic reaction. References | Related Articles | Metrics

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Analysis of 30 Cases Adverse Drug Reaction Induced by Prednsone CHEN Pei-yao 2010, 7(10): 626-628.  Abstract ( 261 )   PDF (647KB) ( 480 )   Objective To analysze the categories and character of Prednsone to cause adverse reaction, in order to provide information of clinical rational administration. Methods To classification statistic and analyses Prednsone to cause 30 cases adverse reaction in medicine periodical report from 1994. Results The manifest ADR of Prednsone was central and perpheral nervous system disorders(25%), muscualoskeletal system disorders(12.5%), gastro-intestinal system disorders (12.5%), metabolic and nutritional disorders(10.42%), respiratory system disorders(6.25%). Conclusion We should think highly of ADR of Prednsone and insist on rational administration. References | Related Articles | Metrics