Chinese Journal of Pharmacovigilance ›› 2010, Vol. 7 ›› Issue (10): 585-589.

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Antitumor Activities of Huanglianjiedu Decoction in Vivo and in Vitro

SUN Jian1,2, YU You-hua2 ,ZHANG Zheng-yao1 ,ZHANG Yang1, ZHOU Qiu-li1   

  1. 1.School of Pharmacy, Jilin University, Jilin Changchun 130021, China;
    2.Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • Received:2010-08-04 Revised:2016-03-12 Online:2010-10-08 Published:2016-03-09

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Abstract: Objective To study the antitumor activities of Huanglianjiedu Decoction(HLJDT) in vivo and in vitro. Methods Antitumor activities were tested in mice with experimental tumor S180 and MFC in vivo, thymus index, spleen index, tumor inhibitory rate were evaluated. Cell proliferation was assayed by using methyl thiazolyl tetrazolium (MTT) method in vitro. S180, MFC, SGC -7901 and SMMC -7721 cancer cells were incubated in culture media containing HLJDT. Results HLJDT showeda Antitumor activities on S180 and MFC in vivo. All of the HLJDT in different dosage groups could highly inhibit the proliferation of 4 cancer cells. Conclusion The HLJDT could inhibit the tumor S180, MFC in mice, the drug has obvious anticancer effects against S180, MFC, SGC -7901 and SMMC7721.

Key words: Huanglianjiedu Decoction(HLJDT), antitumor activity, in vivo, in vitro

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