Abstract: Objective To compare the acute toxicity of different components in Cortex Periplocae on mice which is all components、water extraction components and alcohol extraction components, make an observation and evaluation of acute toxicity to Cortex Periplocae herbs in order to provide a basis for safe and reasonable medication in clinical. Methods Respectively prepare the all components、water extraction components and alcohol extraction components, and compare the acute toxicity of different components in Cortex Periplocae on mice in accordance with classical acute toxicity test methods, and the experimental datas are calculated LD50 with the Bliss method and MTD method, with the continuous administration and observation for 14 days. Results the all components in Cortex Periplocae is unable to make LD50, MTD Results calculated in accordance with crude drug content is respectively 16.0g·kg^-1·d^-1,which is equal to 186.6 times of 70kg people's daily dried medicinal herb expenses. The LD50 of water extraction components and alcohol extraction components in Cortex Periplocae are 93.578g·kg^-1·d^-1 and the 95% confidence limit is 89.149～98.484g·kg^-1·d^-1 which is equal to1 091.8 times of 70kg people's daily dried medicinal herb expenses and 61.388g·kg^-1·d^-1 and the 95% confidence limit is 57.466～65.521g·kg^-1·d^-1 which is equal to 716.2 times of 70kg people's daily dried medicinal herb expenses. The main toxical symptoms and signs are the convulsions, tetraplegia, diarrhoea and the respiratory depression, the deaths mainly occurred in less than 48 hours used by the all components、water extraction components and alcohol extraction components. Conclusion The acute toxicity of different components in Cortex Periplocae on mice is: alcohol extract>water extract>all-components.

Key words: Cortex Periplocae , all-components, water extract, alcohol extract, acute toxicity