Acute Toxicity of Mangrove Plant Lumnitzera racemosa Extract on Mice

doi:10.19803/j.1672-8629.2020.02.02

Abstract

Abstract: Objective To study the acute toxicity of different extracts of branches and leaves from mangrove Lumnitzera racemosa Willd. on mice. Methods After intragastric administration of the water or 70% ethanol extract of branches and leaves from Lumnitzera racemosa Willd. in mice, the urine and stools, activities, diet and death were observed daily. The median lethal dose (LD50) and 95% confidence intervals (95% CI) were calculated with the Karber method. Results The LD50 of the water extract was calculated to be 65.47 g·kg-1 and the 95% CI was 56.78~75.68 g·kg-1, compared with 62.26 g·kg-1 for 70% ethanol extract and 53.29~70.97 g·kg-1 for the 95% CI. Conclusion The Lumnitzera racemosa Willd. extracts have some toxicity that is related to the concentration of the drug.

Key words: mangrove plant, Lumnitzera racemosa, acute toxicity

CLC Number:

R994.21

CHEN Qingshu, CAI Shaofang, TAN Yuanfeng, WEI Wei, NING Xiaoqing. Acute Toxicity of Mangrove Plant Lumnitzera racemosa Extract on Mice[J]. Chinese Journal of Pharmacovigilance, 2020, 17(2): 72-74.

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