Abstract: The purpose is to investigate immune tolerance and the efficacy of hepatitis B vaccine and BCG immunization of infants on the prevention of mother to child transmission(PMTCT) programs, in order to provide the basis for corresponding vaccination policy. We provide PMTCT service to HIV -positive mothers and define infants of HIV-positive mothers as experimental group(EG), while infants beard by HIV-negative mothers as comparative group (CG). The two groups were vaccinated regularly and had PPD tests and anti-HBs level tests. In consequence, the HIV prevalence in infants born to mothers on the PMTCT programs is substantially lower than infants not in the program.The PPD-positive rates of the both groups are above 90%, and the mean content of anti-HBs for EG and CG are 296.83~3.10mIU/mL and 354.30~2.37mIU/mL respectively. In Conclusion , the efficacy of hepatitis B and BCG vaccine immunization of infants born to HIV-positive mothers is similar to normal infants.

Key words: HIV-exposed infants, vaccination, immunity effect