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10 February 2011, Volume 8 Issue 2 Previous Issue    Next Issue

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Effects of Matrine on Proliferation and Metastasis of Human Endometrial Carcinoma Cell Line Ishikawa LI Jun, XUE Xiao-ou, TANG Bing-hua, NIU Jian-zhao 2011, 8(2): 65-67.  Abstract ( 216 )   PDF (316KB) ( 198 )   Objective To study the effect of Matrine on inflammatory factor IL-8 and NF-кBp65 expression from human endometrial carcinoma cell line Ishikawa. Methods The changes of cell proliferation of Ishikawa cells treated with Matrine were observed by using MTT assay. The cell cycle expressions were determined by flow cytometry.The densities of IL-8 in the supenmatant fluid were measured by ELISA. And NF-кBp65 were determined by western blot assay. Results Matrine could inhibit the proliferation of Ishikawa cells in vitro significantly in a dose and time dependent manner(P<0.05). The G0/G1 phase arrest was induced by treatment after 48 hours(P<0.05). The densities of IL-8 in the supenmatant fluid were decreased. Results revealed that cellular NF-кBp65 levels decreased in Matrine-treated cells at 48 hours(P<0.05). Conclusion Matrine could inhibit Ishikawa cell proliferation, induce G0/G1 phase arrest and by interfering with the NF-кB signaling pathway. References | Related Articles | Metrics

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Clinical Effects of Shenqi Jiangtang Granule Combined with Gliquidone on 170 Patients with Type 2 Diabetes Mellitus LI Guo-qiang, WANG Ya-ping, WANG Zhi-zhong, ZHAO Wen, WANG Jing 2011, 8(2): 68-70.  Abstract ( 234 )   PDF (351KB) ( 368 )   Objective To observe the clinical effects of Shenqi Jiangtang granule(SJG) combined with gliquidone on patients with type 2 diabetes mellitus(T2DM). Methods 170 patients with T2DM were randomly divided into 2 groups. Among those 85 cases in the treatment group were submitted with SJG combined gliquidone by oral-taken, while another 85 cases were treated by oral-taken gliquidong only as the control group. Both groups were treated for 24 weeks. The plasma levels of fasting blood glucose(FBG), blood glucose of post-meal 2 hours(2hBG), blood glucse before lunch, blood glucose before supper, blood-fat as well as glycosylated hemoglobin(HbAlc) were measured before and after treatment,respectively. Results The plasma levels of FBG, HbAlc and blood-fat were improved in both groups, however, the FBG and HbAlc levels in treatment group decreasded more significant(P <0.05). The hospitalization rate and emergency treatment rate were also decreased obviously in both groups.There were 2 hypoglycemia reactions occurrenced in treatment group, while 16 cases developed hypoglycemia reaction in control group. There was significant difference between the two groups(P <0.05). Conclusion It suggested that SJG combined with gliquidone has certain curative effect on T2DM patients, which could reduced FBG, HbAlc levels obviously, and with a few incidence rate of hypoglycemia reaction. Thus, it might be a more safe and effective medication for patients with T2DM. References | Related Articles | Metrics

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A Cross-sectional Study on Existing Circumstance of Anti-infective Agents: Application for Elder Patients with Pulmonary Infections in a Certain Hospital ZHAO Yan, CUI Xin, YANG Xing-hua, ZHANG Hong-bo 2011, 8(2): 71-74.  Abstract ( 243 )   PDF (478KB) ( 93 )   Objective Understand current status of anti-infective agents application and main characteristics of pulmonary infections for elder subjects with pulmonary infections in the cadre wards in a certain hospital by investigating their charts. Discuss risk factors that may influence outcomes of pulmonary infections. Methods Investigate clinical charts of 181 elder patients retrospectively in the cadre wards in this hospital between 2008 and 2009. All data were analyzed by SPSS17.0 software package. Results The effective rate of pneumonia, chronic bronchitis, COPD and acute bronchitis is 87.90%, 95.10%, 96.00% and 71.40%, respectively. Factors that influence the outcomes of pulmonary infections are patients’ age(P =0.062), type of underlying disease(P =0.024) and the continuing use of anti-infective agents(P =0.020). The OR value and 95%CI of those factors are 0.234(0.051, 1.073), 0.223(0.061, 0.819) and 3.260(1.200, 8.856). Conclusion Factors that influence outcomes of pulmonary infections are age of patients, type of underlying disease and continuing use of anti-infective agents. References | Related Articles | Metrics

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The Relationship Between Antimicrobial Consumption and Rates of Bacterial Resistance LIN Zhi-qiang, ZHANG Guo-wei, WANG Da-xuan, FU Xin-yang, GONG Hai-hong 2011, 8(2): 75-80.  Abstract ( 211 )   PDF (546KB) ( 216 )   Objective To explore the relationship between various antimicrobial consumption and bacterial resistance. Methods The defined daily doses(DDDs) every 100 patient days of various antimicrobial drugs and the rate of drug resistance of staphylococcus aureus, enterococcus, escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa, acinetobacter baumannii were calculated every six months from 2006 to 2009,then the data were analyzed by the method of multiple linear regressio. Results The rate of resistance of Staphylococcus aureus to erythromycin was significantly negatively associated with the usage of first generation cephalosporins. The rate of resistance of staphylococcus aureus to clindamycin was significantly positively associated with the usage of tetracyclines. The rate of resistance of enterococcus to ampicillin was significantly negatively associated with the usage of broad-spectrum penicillin. A positive correlation was found between the consumption of carbapenems and the resistance of Escherichia coli to ceftazidime, the resistance to aztreonam positively associated with the usage of quinolones, the resistance to amikacin positively associated with the usage of broad-spectrum penicillin. A negative correlation was found between the consumption of fourth-generation cephalosporins and the resistance of klebsiella pneumoniae to amikacin, the resistance to ceftazidime and cefepime negatively associated with the usage of broad-spectrum penicillin. A negative correlation was found between the consumption of β-lactamase inhibitors and the resistance of pseudomonas aeruginosa to piperacillin-tazobactam ceftazidime, cefepime and amikacin. The rate of resistance of acinetobacter baumannii to imipenem had a positive correlation with the usage of carbapenems. Conclusion There exists correlation between antimicrobial consumption and rates of bacterial resistance. References | Related Articles | Metrics

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Experimental Study on the "Dose-Time-Toxicity" Relationship of Hepatotoxicity Induced by Different Components from Radix et Rhizoma Sophorae Tonkinensise in Mice LI Su-jun, LV Li-li, QIAN Xiao-lu, LI Xiao-yu, SUN Rong 2011, 8(2): 81-84.  Abstract ( 228 )   PDF (517KB) ( 246 )   Objective The "dosage-time-toxicity" relationship of hepatotoxicity induced by multiple administration of water extract and alcohol extract of Radix et Rhizoma Sophorae Tonkinensise to mice was studied. Methods Mice are divided into different groups such as normal group, water extract group and alcohol extract group, and the normal conditions were observed after seven days administrated. And the activity of ALT、AST、AKP、TBI、ALB in serum, the liver weight and volume ratio, the changes of liver morphology was observed separately on the d1、d3、d7 after administration. Results The rat's body weight was effected, both the activity of ALT、AST、AKP in serum and TBI were increased, while the ALB was decreased, the liver weight and volume ratio was increased, and the liver pathology tissue changed after given water extract and alcohol extract from Radix et Rhizoma Sophorae Tonkinensise to mice by intragastric for 7 days. These changes were reduced on the 3th day after ig and on the 1th day after ig, thesechanges with the high, medium dosage were reduced again, but the low dosage didn't have these phenomenon especially the water extract. Conclusion Multiple intragastric administrations of water extract and alcohol extract of Radix et Rhizoma Sophorae Tonkinensise with certain dosage may induce acute hepatotoxical injury in mice especially the water extract and this show an obvious "dosage-time-toxicity" relationship. References | Related Articles | Metrics

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The Research on Mechanism of Liver Toxicity Caused by Radix et Rhizoma Sophorae Tonkinensise Lv li-li, LI Su-jun, QIAN Xiao-lu, ZHENG Li-na, SUN Rong 2011, 8(2): 85-88.  Abstract ( 224 )   PDF (504KB) ( 185 )   Objective To investigate the mechanisms of liver toxicity induced by different components from Radix et Rhizoma Sophorae Tonkinensise in mice. Methods Mice are divided into different groups such as normal, water extract and alcohol extract group to observe the SOD、NOS、GSH-Px、MDA、NO and GSH separately on the d1,d3, d7 after seven days administration. Results The SOD、GSH-Px and GSH were decreased ;while the NOS,MDA, NO were increased after given water extract and alcohol extract from Radix et Rhizoma Sophorae Tonkinensise to mice. These changes were enhanced with the increasing of dose and time. Conclusion Multiple intragastric water extract and alcohol extract of Radix et Rhizoma Sophorae Tonkinensise with certain dosage can induce acute hepatotoxic injury in mice, and it is related to the peroxidation. References | Related Articles | Metrics

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Experimental Study on Chronic Toxicity in Rats Caused by Water Extract Components of Radix et Rhizoma Sophorae Tonkinensise LI Su-jun, YANG Qian, QIAN Xiao-lu, SUN Hu, SUN Rong 2011, 8(2): 89-92.  Abstract ( 187 )   PDF (717KB) ( 218 )   Objective The obvious toxical symptoms and signs, the toxic damage extents and reversibility were observed in rats caused by water extract of Radix et Rhizoma Sophorae Tonkinensise. Methods The 80 rats were divided into four groups such as normal group and water extract of high, medium and low dose. The general conditions including the bodyweight、diet and behavior were observed, the blood routine, the biochemical indicators, organ/bodyweight rate, the important organs such as heart, liver, spleen, lung, kidney, brain and et al, and pathological changes were detected after water extract administrated, and then the changes were observed during the recovery period. Results The Wistar rat’s weight, diet and drinking were decreased; the ALT、AST、ALP were increased; the liver weight and volume ratio was increased after given water extract from Radix et Rhizoma Sophorae Tonkinensise to Wistar rats by intragastric for 27 days. Pathological examination showed different degree of liver pathology tissue damage; There was little affect for routine blood; The damage of liver toxicity in rats show an obvious dosage relationship. And after the convalescence, the partial lesions were irreversible. Conclusion The main chronic toxical damage is the changes of ALT、AST、ALP、BUN、CRE in rats caused by water extract of Radix et Rhizoma Sophorae Tonkinensise, and part of the lesions were irreversible. References | Related Articles | Metrics

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Study on the Development of Quality Management Concepts in Pharmaceutical Manufacturers LI Pan-hai, LI Jin-qi, FAN Qiu-ying, FENG Qiao-qiao 2011, 8(2): 93-96.  Abstract ( 278 )   PDF (559KB) ( 168 )   The development process of quality management concepts in pharmaceutical manufacturers in China was reviewed. The status and problems on the quality management concepts was analyzed and the measures to enhance quality management concept was also proposed in this paper, so as to further improve the control capacity on quality risks of drug manufacturing enterprise and to promote the overall improvement of drug security situation in China. References | Related Articles | Metrics

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The Risk Assessment System for Omeprazole Enteric-coated Capsules Manufacturing XU Wan-kui, YUE Qing-yang, PAN yang 2011, 8(2): 97-99.  Abstract ( 268 )   PDF (508KB) ( 224 )   The manufacturing quality and risk of drug is different, because the manufactring process and environment is different. This paper establishes the integrated risk evaluation system by evaluating 9 risk factors including concentration fluctuations of Omeprazole Enteric-coated Capsules through 32 factories’ products. The purpose of this system is to provide the directed supervision object for government. References | Related Articles | Metrics

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Experience of Pharmacist Carrying out Clinical Pharmaceutical Care in Old Cadre Ward YI Dan, TANG Xian-bin, LU Xiang-hong, LI Zheng-chu 2011, 8(2): 100-101.  Abstract ( 182 )   PDF (576KB) ( 179 )   Objective To explore pharmacists'Methods and experience of clinical pharmaceutical care in old cadre ward. Methods main contents, work styles and Results of clinical pharmaceutical care were introduced. Results and Conclusion Carrying out clinical pharmaceutical care thoroughly in clinical ward round by pharmacist is important to provide the safe, effective, rational, economic pharmacentical care for the patients. References | Related Articles | Metrics

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The Risk Management During Drug Withdraw in Hospital Pharmacy KONG Fei-fei, TAN Xing-qi, GUO Liang-jun, FU Ming-qiang, WU Ying-ying 2011, 8(2): 102-104.  Abstract ( 255 )   PDF (573KB) ( 410 )   The large numbers of medical personnel had been attracted on the attention of the risks during the drug withdraw. From the basic concept of risk management drugs, risks that can easily arise during drug withdraw in hospital pharmacy were described and analyzed. And investigate the risk factors and countermeasures of the drug withdraw in hospital pharmacy, Then suggest that, the hospital further regulate the flow of drug withdrawal pharmacy, rigorous review of the pharmacy drug withdrawal, and reduce the risk of drug withdrawal pharmacy hidden, thus ensure drug quality, further promote medical safety. References | Related Articles | Metrics

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Research Progress on Toxicity of Sophora Tonkinensis Based on Efficacy and Material Basis LV Li-li, XIE Yuan-zhang, SUN Rong 2011, 8(2): 105-107.  Abstract ( 227 )   PDF (538KB) ( 352 )   Objective To identify its effective and toxical composition, offer the accordance and study ideas for further research on the relationship between efficacy, toxicity and material foundation of Sophora tonkinensis, by summarizing the current states of material foundation of Sophora tonkinensis related with its efficacy and toxicity. Methods The published references of Sophora tonkinensis were collected, analysised and summarized in the recent 30 years. Results The obvious toxicial effects have been reported of Sophora tonkinensis in Pharmacopoeia and current references, although there is no obvious toxicial effects have been recorded in angent books, such as<Shen nong Ben Cao Jing>,<Ben Cao gang mu>et. The main toxical systems and signs were nausea, diarrhea, chest distress and cardiopalmus. The chemical material foundation, process in vivo, characters and mechanism of toxical effect even though the dosage ranges of efficacy and toxicity have not been reported yet, and investgated regularly. Conclusion There is little perfect study reports of Sophora tonkinensis related to its toxicity, especially the toxicial study based on the efficacy and material foundation. It's urgent that the toxicity of Sophora tonkinensis related to the characteristics of TCM to be identified correctly and studied scientifically in order to provide experimental data, investgating ideas and evidences for the good use in clinic. References | Related Articles | Metrics

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Modern Pharmacology and Toxicology Research Progress of Yangxue Shengfa Capsules ZHENG Li-na, SUN Rong 2011, 8(2): 108-110.  Abstract ( 314 )   PDF (557KB) ( 343 )   Objective Pharmacological and toxicological studies on Yangxue Shengfa Capsules are reviewed, in order to provide information for safe, effective and rational use of the medicine clinically. Method Collect, analyze and summarize domestic related literature in recent twenty years. From nourishing blood, hair growth, itching, allergy and other aspects ,pharmacological studies on Yangxue Shengfa Capsules are reviewed; germinal capsule review; From acute toxicity, liver toxicity, effects on the reproductive system and other aspects , the toxicological studies on Yangxue Shengfa Capsules are reviewed. Results Yangxue Shengfa Capsules has the pharmacological effects of nourishing blood, hair growth, itching, allergy and so on, and has curative effect in clinical. But the long-term use can cause liver damage, hepatitis and other side effects. At present less toxic studies on the whole prescription, but only for every medicines in the prescription, especially the liver toxicity of Radix Polygoni Multiflori. Conclusion Yangxue Shengfa Capsules has significant clinical effect, but its long-term use can cause liver damage, hepatitis and other side effects. Systematical pharmacodynamics evaluation on the therapeutic effect, research on the toxicology of adverse drug reaction(ADR) report of Yangxue Shengfa Capsules, pharmacological and toxicological mechanisms and its related material basis still need to be researched deeply. References | Related Articles | Metrics

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Analysis of Document and Monitoring Data of Diphenoxylate Abuse MA Jun-li, PANG Li-yan, WANG Xiu-juan, ZHOU Li-xin, ZHANG Li-ming 2011, 8(2): 111-112.  Abstract ( 255 )   PDF (521KB) ( 638 )   Diphenoxylate is a ramification of meperidine and has similar pharmacology reaction with opioid. Monitoring data of these years indicated that drug abuser did use diphenoxylate and overdose of diphenoxylate can lead to poisoning. There are also some case reports about diphenoxylate abuse in normal people. This paper tentatively introduced abuse document and monitoring data of diphenoxylate in order to reveal abuse tendency and to promote intelligent use of this substance. Hoping this paper can provide some information for drug administration. References | Related Articles | Metrics

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Analysis of 357 Cases of Adverse Drug Reaction/Event Reports of Anti-infective Agents JIN Wei-hua, WANG Xiao-hui, CHEN Hua, TAN Yong-hong 2011, 8(2): 113-116.  Abstract ( 261 )   PDF (659KB) ( 224 )   Objective To review and analyze the various adverse reaction of anti-infective agents bacterials in order to provide the basis for clinical rational drug use. Methods Data of report adverse drug reaction of anti-infective agents from January 2004 to November 2009 in our hospital were collected. The condition of patients, clinical manifestations of adverse reaction, route of administration, types of antibacterials, types of anti-infection and causality assessment were analyzed. Results 357 cases of adverse reaction of anti-infective agents were involved in the study. The most adverse reaction were caused by quinolones(114 cases, 31.93%), and the cephalosporins followed(67 cases, 18.77%). The most two vulnerable system/organ were skin and its appendages(162 cases, 45.38%), and digestive system(93 cases, 26.05%). Antibiotics for respiratory anti-infective use cause the largest number of cases of adverse reaction(152 cases, 42.58%), followed by anti-infection after surgery(79 cases, 22.13%). Conclusion Irrational use of anti-infective agents was the main reason for the adverse drug reaction/event. Medical institutions should pay more attention to the adverse reactions of anti-infective agents, and strengthen supervision of clinical use of anti-infective agents. References | Related Articles | Metrics

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Analysis of Irrational Use of Drugs from 35 Death Cases in Adverse Drug Reaction Report LIU Xi-li, XU Yan, LIU Xiu-juan, HUANG Yan, DENG Jian-xiong 2011, 8(2): 117-118.  Abstract ( 265 )   PDF (639KB) ( 336 )   Objective In order to explore and solve the problems of the irrational use of drugs, this study tried to analysis the dead cases from aduerse drug reaction(ADR) report database of Guangdong in 2009. Methods Screen the ADR report database of Guangdong in 2009 by Guangdong ADR monitoring system, select all of the death cases, abandon the deficient ones, then analysis the problems and frequencies of the irrational use of drugs. Results 25.71%(12/35) death cases were associated with irrational use of drugs. The frequencies of drug abuse are 25%, 35.71% and 38.46% in municipal hospitals,county hospitals and township hospitals respectively. Furthermore, six dead cases may be blamed for inappropriate rescue, while five happened in township hospitals. The six concerns of irrational use of drugs were overdose,incompatibility, solvent selection error, beyond indications, drug selection error and Repeat medication. Conclusion Irrational use of drugs was common, especially in elementary hospital. The training and education of rational use of drugs for the staff of elementary hospital should be strengthened. References | Related Articles | Metrics

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One Case of Anischuria and Atrioventricular Block Induced by Huperzine-A Tablets CHEN Ying, WU Xiao-yan, QU Fa-lin 2011, 8(2): 118-118.  Abstract ( 244 )   PDF (1127KB) ( 172 )   References | Related Articles | Metrics

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One Case of Severe Anaphylactoid Reaction Induced by Hemocoagulase for Injection JI Lei, WANGJi-mei 2011, 8(2): 119-119.  Abstract ( 226 )   PDF (528KB) ( 256 )   References | Related Articles | Metrics

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One Case of Anaphylactic Shock Induced by Oxaliplatin Injection FANGXiang-hong, DINGXi, ZHANGYan-hua 2011, 8(2): 120-120.  Abstract ( 202 )   PDF (525KB) ( 292 )   References | Related Articles | Metrics

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One Case of New and Severe Adverse Drug Reaction Induced by 999 Coldrine JINGYun-yun 2011, 8(2): 121-121.  Abstract ( 313 )   PDF (523KB) ( 595 )   References | Related Articles | Metrics

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Two Cases of Severe DysaudiaInduced by Tinidazole and Quinolone ZHOU Shu-xiang 2011, 8(2): 122-123.  Abstract ( 223 )   PDF (1127KB) ( 204 )   References | Related Articles | Metrics

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One Case of Actino-anamnestic Reaction Induced Bygemcitabine Hydrochloride for Injection QIYa-jun 2011, 8(2): 123-123.  Abstract ( 206 )   PDF (556KB) ( 302 )   References | Related Articles | Metrics

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One Case of Anaphylactic Shock Induced by Aztreonam for Injection PIAOHai-jin 2011, 8(2): 124-124.  Abstract ( 212 )   PDF (986KB) ( 288 )   References | Related Articles | Metrics

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Medication Errors: Pharmacovigilance Centres in Detection and Prevention QIU Xiao-yan(Translation), LI Qun-yi(Proofreading) 2011, 8(2): 125-125.  Abstract ( 195 )   PDF (986KB) ( 250 )   Related Articles | Metrics

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The Epidemiology of Medication Errors: the Methodological Difficulties SHEN Jian-wen(Translation), FU Wen-huan(Proofreading) 2011, 8(2): 126-128.  Abstract ( 195 )   PDF (578KB) ( 167 )   Related Articles | Metrics