Abstract: Objective To review and analyze the various adverse reaction of anti-infective agents bacterials in order to provide the basis for clinical rational drug use. Methods Data of report adverse drug reaction of anti-infective agents from January 2004 to November 2009 in our hospital were collected. The condition of patients, clinical manifestations of adverse reaction, route of administration, types of antibacterials, types of anti-infection and causality assessment were analyzed. Results 357 cases of adverse reaction of anti-infective agents were involved in the study. The most adverse reaction were caused by quinolones(114 cases, 31.93%), and the cephalosporins followed(67 cases, 18.77%). The most two vulnerable system/organ were skin and its appendages(162 cases, 45.38%), and digestive system(93 cases, 26.05%). Antibiotics for respiratory anti-infective use cause the largest number of cases of adverse reaction(152 cases, 42.58%), followed by anti-infection after surgery(79 cases, 22.13%). Conclusion Irrational use of anti-infective agents was the main reason for the adverse drug reaction/event. Medical institutions should pay more attention to the adverse reactions of anti-infective agents, and strengthen supervision of clinical use of anti-infective agents.

Key words: anti-infective agents, adverse drug reaction/event, analysis