Chinese Journal of Pharmacovigilance ›› 2025, Vol. 22 ›› Issue (8): 920-923.
DOI: 10.19803/j.1672-8629.20240986

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Clinical Applications of Jinhua Qinggan Granules in the Treatment of Mild Influenza: a Meta-Analysis

YING Jie1, XU Xiaolong2,3,4, LI Bo2,3, LIU Tengwen5, LIU Qingquan2,3,4*   

  1. 1Clinical Medical College of Beijing University of Chinese Medicine, Beijing 100020, China;
    2Emergency Department, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China;
    3Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China;
    4Laboratory for Clinical Medicine, Capital Medical University, Beijing 100010, China;
    5Basic Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu Sichuan 610075, China
  • Received:2024-12-12 Online:2025-08-15 Published:2025-08-13

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Abstract: Objective To explore the clinical efficacy of Jinhua Qinggan granules in the treatment of mild influenza. Methods Such databases as PubMed, Embase, Web of Science, Cochrane Library, CNKI, VIP and Wanfang were searched for related literature that was collected from the inception to August 30, 2024. Randomized controlled trials (RCTs) about Jinhua Qinggan granules used for mild influenza were included following Cochrane systematic review guidelines. Meta-analysis was performed using Stata 16.0. Results A total of 1 085 patients were included. For the low-dose Jinhua Qinggan granules (5 g/dose), the efficacy of syndrome-based treatment with TCM was 9.23% higher than that of the placebo [95%CI (5.30, 13.15)] after three days of treatment despite potential publication bias. The fever resolution rate of three days of treatment with low-dose Jinhua Qinggan granules was 7.31% higher than that of placebo [95%CI (3.04, 11.59)], with no publication bias detected by Begg's test. After five days of treatment, there was no significant difference in improvement of TCM syndromes compared to the placebo, but the fever resolution rate was 1.92% higher (95%CI [-2.74, 6.58]), with no publication bias observed by Begg's test. High-dose Jinhua Qinggan granules (10 g/dose) showed no advantage in improving TCM syndromes or the fever resolution rate compared to the control groups. Conclusion Jinhua Qinggan granules prove to be effective for mildinfluenza by alleviating TCM clinical symptoms and accelerating fever resolution.

Key words: Mild Influenza, Jinhua Qinggan Granules, Meta-Analysis, Randomized Controlled Trial, Evidence-Based Medicine

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