Systematic Evaluation of Cardiotoxicity of Chinese Herbal Compounds for Breast Cancer Chemotherapy

doi:10.19803/j.1672-8629.20240449

Abstract

Abstract: Objective To evaluate the applicability and therapeutic effect of Chinese herbal compounds in preventing and treating chemotherapy-induced cardiotoxicity in breast cancer patients. Methods Data on randomized controlled trials (RCTs) of Chinese herbal compounds for chemotherapy-induced cardiotoxicity in breast cancer patients published in domestic and foreign databases was collected and sortde from establishment of the tibrary to April 1, 2024. Excel sheet was used to analyze the related medications while RevMan 5.4 software was adopted to perform Meta-analysis on RCTs that met the inclusion criteria. Results A total of 42 RCTs were included, involving 2 847 subjects. The experimental group was treated with Chinese herbal compounds plus conventional chemotherapy to combat chemotherapy-induced cardiotoxicity. Compared with the control group treated with chemotherapy drugs alone, the incidence of abnormal electrocardiograms was significantly reduced in the experimental group OR=0.23[95%CI (0.19, 0.28), P<0.000 01]. In addition, the left ventricular ejection fraction was increased with an MD of 9.02[95%CI (6.45, 11.60), P=0.000 1], but the expressions of creatine kinase isoenzyme and troponin I were reduced. Conclusion Chinese herbal compounds capable of replenishing qi and nourishing yin, promoting blood circulation and unblocking meridians have prominent advantages in preventing and treating the cardiotoxicity induced by chemotherapy drugs.

Key words: Chinese Herbal Compound, Cardiotoxicity, Meta-analysis, Breast Cancer, RCTS, Chemotherapy, Pharmacovigilance

CLC Number:

LIU Shujia, ZHANG Xiaomeng, CHEN Siying, CAI Haili, ZHANG Bing. Systematic Evaluation of Cardiotoxicity of Chinese Herbal Compounds for Breast Cancer Chemotherapy[J]. Chinese Journal of Pharmacovigilance, 2024, 21(11): 1209-1215.

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