Research Progress in Drugs for Brain Metastases from Advanced Breast Cancer

doi:10.19803/j.1672-8629.20250055

Abstract

Abstract: Objective To analyze the current drug therapies for brain metastases from breast cancer (BCBM) and to explore innovative therapeutic strategies for overcoming the blood-brain barrier (BBB) and blood-tumor barrier (BTB) so as to enhance the clinical efficacy of treatments for patients with advanced BCBM. Methods Based on subtypes of breast cancer, novel antitumor drugs were classified and their respective clinical efficacy in BCBM was summarized. Results With the incessant development and marketing of novel anti-tumor drugs, small-molecule kinase inhibitors, such as antibody-drug conjugates and novel nanomedicines, demonstrated their potential applications in the treatment of BCBM. Conclusion The pathogenesis of BCBM requires more in-depth studies in the future, and more effective therapeutic agents need to be developed to improve life quality of patients.

Key words: Advanced Breast Cancer, Brain Metastasis, Blood-Brain Barrier, Blood-Tumor Barrier, Medication Treatment, Research Progress

CLC Number:

R979.1

YE Ling, LIU Xiaoying, DANG Xuefei, LI Xuelian, LI Gang. Research Progress in Drugs for Brain Metastases from Advanced Breast Cancer[J]. Chinese Journal of Pharmacovigilance, 2025, 22(6): 714-720.

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URL: https://zgywjj.magtechjournal.com/EN/10.19803/j.1672-8629.20250055

https://zgywjj.magtechjournal.com/EN/Y2025/V22/I6/714

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