Chinese Journal of Pharmacovigilance ›› 2020, Vol. 17 ›› Issue (5): 267-271.
DOI: 10.19803/j.1672-8629.2020.05.03

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The Role of Renin-angiotensin System in COVID-19 and Drug Intervention

LI Sizheng1,2, HU Guang1, HE Jingcheng3, HU Yuchi4, LI Zhiyong5, JIN Hongtao1, 6*   

  1. 1 New Drug Safety Evaluation Center, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;
    2 College of Pharmacy, Nankai University, Tianjin 300350, China;
    3 Shunde Hospital of Southern Medical University, Foshan Guangdong 528000, China;
    4 Beijing Institute For Drug Control, Beijing 102206, China;
    5 School of Pharmacy, Minzu University of China, Beijing 100081, China;
    6 Beijing Union-Genius Pharmaceutical Technology Co.,Ltd, Beijing 100176, China
  • Received:2020-03-16 Revised:2020-06-22 Online:2020-05-15 Published:2020-05-13

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Abstract: The pathogenesis of COVID-19 is characterized by fever, dry cough and fatigue. In severe cases, it may progress to acute respiratory distress syndrome (ARDS), etc., and even death. SARS-CoV-2 can invade cells through angiotensin-converting enzyme 2 (ACE2) and cause down-regulation of ACE2 expression. The down-regulation of ACE2 expression can lead to the imbalance of renin-angiotensin system (RAS), which leads to the occurrence of subsequent pathological states. RAS also plays an important role in ARDS. This review summarized the possible roles of RAS in the pathogenesis of COVID-19, as well as treatment of COVID-19 based on RAS, hoping to optimize the treatment and provide reference information.

Key words: COVID-19, angiotensin-converting enzyme 2, renin-angiotensin system, lung injury, pathological effects, research progress

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