Research Progress in Regulation of Wnt/β-Catenin Signaling Pathway by TCM in the Treatment of Ischemic Stroke

doi:10.19803/j.1672-8629.20240653

Abstract

Abstract: Objective To study the role of the Wnt/β-catenin signaling pathway in acute ischemic stroke (IS), and to summarize the mechanisms by which traditional Chinese medicine formulas and monomers exert therapeutic effects on IS through the Wnt/β-catenin signaling pathway. Methods By searching related literature at home and abroad, traditional Chinese medicine formulas and their monomers currently available were summarized, and future developments were predicted. Results Traditional Chinese medicine could effectively alleviate brain damage caused by IS by targeting the Wnt/β-catenin signaling pathway, including anti-inflammation, antioxidant stress, anti neuronal apoptosis, and promotion of angiogenesis. Conclusion In the treatment of IS, traditional Chinese medicine can exert a good effect through the Wnt/β-catenin signaling pathway.

Key words: Ischemic Stroke, Wnt/β-Catenin Signaling Pathway, Traditional Chinese Medicine, Research Progress

CLC Number:

R994.11
R743

LIU Sujie, YAN Jiahe, RUAN Jiaxin, WANG Chen, WANG Xiaofan, LIU Shumin, BAI Xue. Research Progress in Regulation of Wnt/β-Catenin Signaling Pathway by TCM in the Treatment of Ischemic Stroke[J]. Chinese Journal of Pharmacovigilance, 2024, 21(12): 1388-1392.

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URL: https://zgywjj.magtechjournal.com/EN/10.19803/j.1672-8629.20240653

https://zgywjj.magtechjournal.com/EN/Y2024/V21/I12/1388

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