Construction and Application of Knowledge Base for Toxic Herbal Materials

doi:10.19803/j.1672-8629.20240705

Abstract

Abstract: Objective To establish a knowledge base of toxic traditional Chinese medicine. Methods A knowledge graph storage structure combined with visualization technology was adopted to present the information about the toxin-targeted organs and toxic doses. A visualization platform was built for toxic medicinal materials. Results The knowledge base exclusively related to toxic traditional Chinese medicine constructed by the study summarized the reports about toxic experiments on toxic traditional Chinese medicine, traditional Chinese patent medicines and simple preparations containing toxic traditional Chinese medicine and toxic ingredients, integrated the knowledge of toxic traditional Chinese medicine and kept data more correlated. Conclusion This platform will provide data service support for the applicational research, development, and inheritance of toxic traditional Chinese medicine.

Key words: Toxic Traditional Chinese Medicine, Knowledge Base Construction, Knowledge Graph, Adverse Drug Reaction, Toxic Dose

CLC Number:

R917

LI Xiaoyang, WANG Yilin, XU Jing, TONG Lin, ZHAI Min, JIANG Wenbo, HE Yanxian, LEI Lei, YOU Yun. Construction and Application of Knowledge Base for Toxic Herbal Materials[J]. Chinese Journal of Pharmacovigilance, 2024, 21(12): 1415-1418.

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https://zgywjj.magtechjournal.com/EN/Y2024/V21/I12/1415

References

[1] National Pharmacopoeia Commission.Pharmacopoeia of the People's Republic of China. Volume Ⅰ (中华人民共和国药典一部 ) [M]. Beijing: China Medical Science Press, 2020.
[2] XU L, YAN DM, NIE HY, et al.Reflection and Exploration on the Toxicity Grading Standards of Traditional Chinese Medicine Based on the Current Status of Toxic Medicinal Materials Standards in the 2020 Edition of the Chinese Pharmacopoeia[J]. Journal of Chinese Medicinal Materials(中药材), 2021, 44(5): 1041-1045.
[3] HOOFNAGLE JH, SERRANO J, KNOBEN JE, et al.LiverTox: A Website on Drug-Induced Liver Injury[J]. Hepatology, 2013, 57(3): 873-874.
[4] DAVIS AP, WIEGERS TC, JOHNSON RJ, et al.Comparative Toxicogenomics Database(CTD): Update 2023[J]. Nucleic Acids Res, 2023, 51(D1): D1257-D1262.
[5] KUHN M, LETUNIC I, JENSEN LJ, et al.The SIDER Database of Drugs and Side Effects[J]. Nucleic Acids Res, 2016, 44(D1): D1075-D1079.
[6] National Pharmacopoeia Commission. Chinese Materia Medica(中华本草)[M]. Shanghai: Shanghai Scientific & Technical Publishers,1999.
[7] ZHAO H, YANG Y, WANG SQ, et al.NPASS Database Update 2023: Quantitative Natural Product Activity and Species Source Database for Biomedical Research[J]. Nucleic Acids Res, 2023, 51(D1): D621-D628.
[8] WANG X, LI HY, KANG L, et al.Construction and Application of TCM Miner[J]. Chinese Journal of Library and Information Science for Traditional Chinese Medicine(中国中医药图书情报杂志), 2021, 45(4): 1-6.
[9] YOU Y, HUANG FH, HAN L.Advances in Reproduction Toxicity Study on Traditional Chinese Materia Medica Recorded in Chinese Pharmacopoeia as Prohibited or Used with Caution During Pregnancy[J]. Chinese Journal of Pharmacology and Toxicology(中国药理学与毒理学杂志), 2018, 32(5): 364-370.
[10] CHEN RS.Reflection and Evolution of Materia Medica from the Perspective of Understanding and Handling the Toxicity of Chinese Drugs[J]. Journal of Basic Chinese Medicine(中国中医基础医学杂志), 2024, 30(1): 104-107.
[11] CHEN RS, ZHOU YQ.Analysis of Relativity and Variability of Chinese Herbalism Toxicity[J]. Journal of Basic Chinese Medicine(中国中医基础医学杂志), 2012, 18(11): 1257-1259.
[12] YANG YL, WANG YL, GUI XJ.Retrospective Analysis of Rational Use of Aristolochia Manshuriensis[J]. Chinese Journal of Modern Applied Pharmacy(中国现代应用药学), 2020, 37(23): 2925-2931.
[13] XIAN Z.Study on the Toxicity Difference and Mechanism of Representative Aristolochic Acids (AA-I, AA-IVa) in Commonly Used Aristolochiaceae Plants[D]. Beijing: China Academy of Chinese Medical Sciences, 2022.
[14] ZHAO CJ, JIA Z, TANG Y, et al.Exploring the Toxicity Characteristics of Traditional Chinese Medicine Based on The “Toxicity-Effect” Relationship[J]. Global Traditional Chinese Medicine(环球中医药), 2024, 17(8): 1602-1606.
[15] PAN XQ, PENG C.Research Methods and Thoughts on the Integrated Study of the Complex Interaction Network Between “Toxicity and Efficacy” Induced by The Toxic Chinese Materia Medica[J]. China Journal of Traditional Chinese Medicine and Pharmacy(中华中医药杂志), 2023, 38(4): 1421-1425.
[16] HE YH, LI M, LUO XL, et al.Research on Entity and Relation Extraction from Traditional Chinese Medicine Knowledge Graphs Based on GPTs[J]. Shanghai Journal of Traditional Chinese Medicine(上海中医药杂志), 2024, 58(8): 1-6.