Abstract: Objective To explore the research progress in clinical efficacy and mechanisms of action of traditional Chinese medicine compound formulae in the treatment of hemorrhagic stroke in recent years, and to find out more about the potential applications of traditional Chinese medicine compound formulae. Methods Literature related to TCM compound formulae against hemorrhagic stroke that was published from inception to August 2024 was searched for in National Knowledge Infrastructure (CNKI) databases, while related research progress was summarized. Results Clinical studies showed that such TCM compound formulae as Yisui Poxue formula and decoctions for invigorating blood and removing blood stasis could do much to improve the neurological function of patients, reduce cerebral edema, facilitate recovery and improve the quality of life. Studies on the mechanisms suggested that TCM compound formulae could exert such pharmacological effects as protection of neurons, improvement of microcirculation, reduction of inflammatory response, attenuation of oxidative stress, inhibition of apoptosis, pyroptosis and ferroptosis in multi-target and multi-pathway ways. Conclusion With in-depth research, TCM compound formulae are expected to play a greater role in the comprehensive treatment of hemorrhagic stroke and provide patients with more individualized and precise treatment options, but most of the current studies are small-sample observational studies with limited evidence. More high-quality clinical studies are needed in the future to validate the efficacy of TCM compound formulae in the treatment of hemorrhagic stroke.

Key words: Traditional Chinese Medicine Compound Formulae, Hemorrhagic Stroke, Neurons, Clinical Efficacy, Mechanism, Yisui Poxue Formula, Decoctions for Invigorating Blood and Removing