Research Progress in Liver Injury Caused by Drugs Commonly Used during Pregnancy

doi:10.19803/j.1672-8629.20250037

Abstract

Abstract: Objective To provide an overview of the classification, mechanisms, diagnostic methods, and management of drug-induced liver injury(DILI) during pregnancy in order to ensure pharmacovigilance during pregnancy. Methods Such databases as PubMed, the Cochrane Library, the Web of Science, CNKI and CBM were searched for literature related to DILI during pregnancy. Results The incidence of DILI during pregnancy fluctuated. Liver injury was primarily divided into three types: direct, indirect or specific, with the last type dominating during pregnancy. DILI still relied on the diagnosis of exclusion, usually made only after other causes of hepatitis were ruled out. DILI during pregnancy was handled in the same way as in non-pregnant populations. The commonly used drugs that could cause DILI during pregnancy included antihypertensive drugs, anti-thyroid drugs, antiretroviral and anti-tuberculosis drugs as well as antibiotics. Conclusion Research reports on DILI during pregnancy are lacking. Moreover, most of the literature currently available is case reports. The incidence of this disease varies, diagnosis is difficult, and management is challenging. Pharmacovigilance during pregnancy has to be upgraded to ensure the safety of patients.

Key words: Drug-Induced Liver Injury during Pregnancy, Labetalol, Propylthiouracil, Classification and Mechanism, Diagnosis and Management

CLC Number:

CAO Weiping, ZHANG Shichao, NI Xia, XIE Bing, WANG Xinzhi, XING Mengtao. Research Progress in Liver Injury Caused by Drugs Commonly Used during Pregnancy[J]. Chinese Journal of Pharmacovigilance, 2025, 22(5): 528-531.

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