Chinese Journal of Pharmacovigilance ›› 2024, Vol. 21 ›› Issue (3): 241-245.
DOI: 10.19803/j.1672-8629.20230654

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Research progress on animal models of allergic rhinitis

SUN Qiyue, GUO Shanshan, ZHAO Ronghua, BAO Lei, GENG Zihan, LI Shuran, XU Yingli, ZHANG Jingsheng, CUI Xiaolan#, SUN Jing*   

  1. Institute of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100029, China
  • Received:2023-10-17 Online:2024-03-15 Published:2024-03-18

Abstract: Objective To summarize the research progress on animal models related to allergic rhinitis (AR), providing a reference for further understanding of AR pathogenesis and drug evaluation. Methods Based on a literature review from both domestic and international sources, the types of AR animal models, their characteristics, modeling methods, criteria for successful models, and evaluation indicators were summarized. Results Animal models for allergic rhinitis include both Western medicine pathological models and traditional Chinese medicine combination models. Commonly used animals include guinea pigs, mice, rats, and New Zealand rabbits. Conclusion This review provides insights into existing AR animal models, their methods, and evaluation criteria, offering valuable guidance for future AR research.

Key words: allergic rhinitis, animal model, mechanism, evaluation indicators, Guinea pigs, mice, rats, New Zealand rabbits

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