Abstract: Objective To observe the clinical effects of Shenqi Jiangtang granule(SJG) combined with gliquidone on patients with type 2 diabetes mellitus(T2DM). Methods 170 patients with T2DM were randomly divided into 2 groups. Among those 85 cases in the treatment group were submitted with SJG combined gliquidone by oral-taken, while another 85 cases were treated by oral-taken gliquidong only as the control group. Both groups were treated for 24 weeks. The plasma levels of fasting blood glucose(FBG), blood glucose of post-meal 2 hours(2hBG), blood glucse before lunch, blood glucose before supper, blood-fat as well as glycosylated hemoglobin(HbAlc) were measured before and after treatment,respectively. Results The plasma levels of FBG, HbAlc and blood-fat were improved in both groups, however, the FBG and HbAlc levels in treatment group decreasded more significant(P <0.05). The hospitalization rate and emergency treatment rate were also decreased obviously in both groups.There were 2 hypoglycemia reactions occurrenced in treatment group, while 16 cases developed hypoglycemia reaction in control group. There was significant difference between the two groups(P <0.05). Conclusion It suggested that SJG combined with gliquidone has certain curative effect on T2DM patients, which could reduced FBG, HbAlc levels obviously, and with a few incidence rate of hypoglycemia reaction. Thus, it might be a more safe and effective medication for patients with T2DM.

Key words: type 2 diabetes mellitus(T2DM), Shenqi Jiangtang granule(SJG), gliquidone, hypoglycemia reaction