A Cross-sectional Study on Existing Circumstance of Anti-infective Agents: Application for Elder Patients with Pulmonary Infections in a Certain Hospital

Abstract

Abstract: Objective Understand current status of anti-infective agents application and main characteristics of pulmonary infections for elder subjects with pulmonary infections in the cadre wards in a certain hospital by investigating their charts. Discuss risk factors that may influence outcomes of pulmonary infections. Methods Investigate clinical charts of 181 elder patients retrospectively in the cadre wards in this hospital between 2008 and 2009. All data were analyzed by SPSS17.0 software package. Results The effective rate of pneumonia, chronic bronchitis, COPD and acute bronchitis is 87.90%, 95.10%, 96.00% and 71.40%, respectively. Factors that influence the outcomes of pulmonary infections are patients’ age(P =0.062), type of underlying disease(P =0.024) and the continuing use of anti-infective agents(P =0.020). The OR value and 95%CI of those factors are 0.234(0.051, 1.073), 0.223(0.061, 0.819) and 3.260(1.200, 8.856). Conclusion Factors that influence outcomes of pulmonary infections are age of patients, type of underlying disease and continuing use of anti-infective agents.

Key words: the elderly, pulmonary infection, anti-infective agents

CLC Number:

R916.695

ZHAO Yan, CUI Xin, YANG Xing-hua, ZHANG Hong-bo. A Cross-sectional Study on Existing Circumstance of Anti-infective Agents: Application for Elder Patients with Pulmonary Infections in a Certain Hospital[J]. Chinese Journal of Pharmacovigilance, 2011, 8(2): 71-74.

References

[1] Gaetan Gavazzi, Karl-Heinz Krause. Ageing and infection[J]. The Lancet Infectious Diseases, 2002,2(11):659-666.
[2] P C. Appelbaum, S H. Gillespie, C J. Burley, et al. Antimicrobial selection for community-acquired lower respiratory tract infections in the 21st century: a review of gemifloxacin[J]. International Journal of Antimicrobial Agents,2004,23：533-546.
[3] H B. Fung, M O. Monteagudo-Chu. Community-Acquired Pneumonia in the Elderly Horatio[J].The American Journal of Geriatric Pharmacotherapy, 2010, 8（1）:47-62.
[4] 董碧蓉.临床循证治疗手册（呼吸疾病）[M]. 北京:人民卫生出版社,2008:61-62,144.
[5] 叶任高,陆再英.内科学（第6版）[M]. 北京:人民卫生出版社,2006:14,57.
[6] C H. Lee, C L. Wu. An update on the management of hospital-acquired pneumonia in the elederly[J]. International Journal of Gerontology, 2008, 2(4):183-195.
[7] D J. MICK. Pneumonia in Elders[J].Geriatric Nursing, 1997:99-102.
[8] S C. Nicholson,K P. High,S. Gothelf,et al. Gatifloxacin in community-based treatment of acute respiratory tract infections in the elderly[J].Diagnostic Microbiology and Infectious Disease,2002, 44:109-116.
[9] 朱惠莉, 龚瑾,符礼刚,等.替考拉宁与万古霉素治疗老年人耐甲氧西林金葡菌肺部感染的评价[J].中国临床医学, 2003,10(2)：183-85.
[10] B M. Greenberg, R L. Atmar, C E.Stager,et al. Bacteraemia in the elderly: predictors of outcome in an urban teaching hospital[J]. Journal of Infection, 2005, 50: 288-295.
[11] 卫生部,中华医学会.中华人民共和国卫生部.抗菌药物临床应用指导原则[EB/OL].2004-08-19[2010-09-10].http://www.moh.gov.cn/publicfiles/business/htmlfiles/wsb/pzcjd/200804/21154.htm.
[12] J W L. Cals, R M. Hopstaken, P H. Le Doux, et al. Dose timing and patient compliance with two antibiotic treatment regimens for lower respiratory tract infections in primary care[J].International Journal of Antimicrobial Agents ,2008,31:531-536.