Chinese Journal of Pharmacovigilance ›› 2011, Vol. 8 ›› Issue (2): 85-88.

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The Research on Mechanism of Liver Toxicity Caused by Radix et Rhizoma Sophorae Tonkinensise

Lv li-li1, LI Su-jun2, QIAN Xiao-lu2, ZHENG Li-na3, SUN Rong1   

  1. 1. Shandong Research Academy of TCM, Shandong Jinan 250014, China;
    2. Shandong University of Traditional Chinese Medicine, Shandong Jinan 250355,China;
    3. Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
  • Received:2015-08-27 Revised:2015-08-27 Online:2011-02-10 Published:2015-08-27

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Abstract: Objective To investigate the mechanisms of liver toxicity induced by different components from Radix et Rhizoma Sophorae Tonkinensise in mice. Methods Mice are divided into different groups such as normal, water extract and alcohol extract group to observe the SOD、NOS、GSH-Px、MDA、NO and GSH separately on the d1,d3, d7 after seven days administration. Results The SOD、GSH-Px and GSH were decreased ;while the NOS,MDA, NO were increased after given water extract and alcohol extract from Radix et Rhizoma Sophorae Tonkinensise to mice. These changes were enhanced with the increasing of dose and time. Conclusion Multiple intragastric water extract and alcohol extract of Radix et Rhizoma Sophorae Tonkinensise with certain dosage can induce acute hepatotoxic injury in mice, and it is related to the peroxidation.

Key words: Radix et Rhizoma Sophorae Tonkinensise, hepatotoxicity, mechanism of liver toxicity

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