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08 June 2015, Volume 12 Issue 5 Previous Issue    Next Issue

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Study on Inhibition Effect and Mechanism of Baicalin on Human Gastric Carcinoma SGC-7901 Cells LI Feng, WANG Geng-wang, QIAN Bin-bin,YANG Sun-hu 2015, 12(5): 257-260.  Abstract ( 374 )   PDF (410KB) ( 214 )   Objective To investigate the inhibiting effect and its mechanism of baicalin on human gastric carcinoma SGC-7901 cells. Methods Growth inhibition rates of SGC-7901 cells were measured with MTT method, the cell cycle distribution was detected by PI single staining, apoptosis was detected by Annexin V/PI double staining, and the expression levels of Bcl-2, bax protein were analyzed by western blot. Results Baicalin inhibited the proliferation of SGC-7901 cells ina dose and time dependent manner. The IC50 of 24h and 48 h were 218.73 μmol·L-1 and 161.86μmol·L-1 respectively. The cell growth was arrested in G2/M phase. Fluorescent staining can detect the apoptotic cells induced by baicalin. The expression of Bax protein was increased while the Bcl-2 was decreased. Conclusion Baicalin not only inhibits proliferation but also induces apoptosis of SGC -7901 cells. Its mechanism is related to down -regulating Bcl-2 while up-regulating Bax. References | Related Articles | Metrics

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Study on Correlation of the Content of Periplocin with Acute Toxicity of Cortex Periploce XU Xin ,MA Zhi-hui ,SUN Da ,CHEN Jin-tang ,ZHOU Kun ,LIU Yang 2015, 12(5): 261-263.  Abstract ( 397 )   PDF (404KB) ( 168 )   Objective To study the correlation of the content of periplocin with acute toxicity of in different places. Methods The content determination of periplocin and 4-methoxy salicylic aldehyde in Cortex Periploce was carried out by HPLC simultaneously. Mice were respectively orally administered with 32g·kg-1 of Cortex Periploce extract, 4-methoxy salicylic aldehyde 200, 250, 300 mg·kg-1, the toxic symptoms and the number of deaths were observed for fourteen days Results The acute toxicity study showed that the mortality in the groups of Cortex Periploce 125.7 g crude drug/kg(containing periplocin 159.552 mg·kg-1), 106.6g crude drug/kg (Containing Periplocin 112.032 mg·kg-1), 111.7g crude drug/kg (containing periplocin 91.584 mg·kg-1), 123.8g crude drug/kg (containing periplocin 93.794 mg·kg-1), 106.6 g crude drug/kg (containing periplocin 46.784 mg·kg-1), 122.6 g crude drug/kg (containing periplocin 98.976 mg·kg-1) were 70%, 20%,0,0,0 and 20% respectively. Linear regression correlation analysis showed that the correlation coefficient was 0.9678. The mortality in the group of 4-methoxy salicylic aldehyde 300 mg·kg-1 was 0 Conclusion There was good correlation between the content of periplocin and the results of the acute toxicity of Cortex Periploce , the toxicity response can be reduced by limiting the content of periplocin. References | Related Articles | Metrics

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A Randomized Controlled Clinical Trial of Tongluozhanshitang in Treatment of Erectile Dysfunction Based on Renal Deficiency and Blood Stasis CHENG Hai-sheng ,ZHANG Tao ,ZHANG Xue-song ,MO Xu-wei ,LI Hai-song 2015, 12(5): 264-266.  Abstract ( 359 )   PDF (452KB) ( 392 )   Objective To evaluate the clinical therapeutic effect of Tongluozhanshitang in treatment of erectile dysfunction. Methods 62 cases of control group were treated by Fufangxuanju capsule, 58 cases of treatment group were treated by Tongluozhanshitang, both for4 weeks. The international index of erectile function (IIEF-5), score of mend sexual life quality questionnaire (mSLQQ), score of symptoms of Chinese medicine (SSCM) were compared between two groups before and after theatment. Results IIEF-5 and mSLQQ of two groups presented siginificant statistical difference( P<0.01). Treatment group was superior to control group. The total effective rate was 82.7% in treatment group, 72.5% in control group. Conclusion Tongluozhanshitang in the treatment of ED has more obvious effectiveness and improvement of life quality than Fufangxuanju capsule. References | Related Articles | Metrics

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Clinical Effects of Atrovastatin Intensive Treatment on Contrast-Induced Nephropathy after Cerebral Vascular Interventional Therapy LIN Hao-hai ,QIN Chao*,CHENG Dao-bin ,DUAN Song-bo ,WEI Xiao-yong 2015, 12(5): 267-270.  Abstract ( 390 )   PDF (436KB) ( 145 )   Objective To investigate clinical effects of atrovastatin intensive treatment on contrast-induced nephropathy (CIN) after cerebral vascular interventional therapy援 Methods 95 cases of patients with cerebral vascular diseases requring cerebral vascular interventional therapy in our hospital from July to December 2014 were divided into the observation group (n=49) and control group (n=46). 72 h before operation and after operation, the observation group was given atrovastatin intensive treatment(80 mg, 40 mg), the control group was given atrovastatin treatment (20 mg). The SCR (serum creatinine), CCR (endogenous creatinine clearance), β2-MG( β2-micro globulin), CYS-C (plasma cystatin), hs-CRP (high sensitivity C reactive protein) of two groups were analyzed 24 h before operation and 72h after operation. Results The postoperative renal function and hs-CRP improvement of the observation group was better than that of the control group(P < 0.05). Conclusion The atrovastatin intensive treatment before cerebral vascular interventional therapy can reduce renal damage and is safe, which may be achieved by inhibition of inflammation factor. References | Related Articles | Metrics

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Comparison and Analysis on Instructions for Foreign and Domestic Aspirin Enteric-coated Tablets ZENG Jing ,ZHUO Lin ,ZHAN Si-yan* 2015, 12(5): 271-274.  Abstract ( 681 )   PDF (494KB) ( 585 )   Objective To improve the domestic instructions by summarizing evidence of the criterion and accuracy of aspirin enteric-coated tablet instructions. Methods Systematic review was applied to identify instructions through foreign and domestic web/databases. Aspirin enteric-coated tablet instructions classified as OTC and produced during 2002-2013 were included. Results 82 copies were eligible and divided into low or high dose type according to the usage and specifications. In terms of domestic instructions, incorrect label of basic items was mainly in the non-safety information, contraindications and precautions, and low-dose instructions were not unified in indications, usage and dosage, etc. As for safety information, we found that two types all had inconsistency in indications, dosage and suitable crowd, and the difference in low dose was more obvious. Conclusion The quality of basic items in domestic instructions was acceptable, but the low-dose safety information was poorly administrated. Compared with others, domestic instructions lacked local researches and we should attach more importance to pediatric use. References | Related Articles | Metrics

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Analysis and Prospect of the Present Situation of Grassroots Level Adverse Drug Reaction Monitoring System Construction in Our Country JIN Feng ,QU Yi ,FAN Ruo-xi ,LI Xin -ling 2015, 12(5): 275-278.  Abstract ( 456 )   PDF (684KB) ( 157 )   Objective Through analyzing researches on the current status of the grassroots adverse drug reaction (ADR) monitoring organization in the country, to provide reference for the food and medicine monitoring organizations at different levels to develop ADR monitoring system, so as to better serve the overall safety monitoring of the medicine, medical device and cosmetic product. Methods Questionnaire survey was used to conduct research on the current status of the local adverse drug reaction monitoring system in our country. Results and Conclusion Through analyzing current status, common issues of the grassroots ADR monitoring organizations are discussed. These issues include incomplete reform progress, insufficient organization functions, most of the organizations not being independent, personnel team needing improvement, etc. The author makes proposals to the future local adverse drug reaction monitoring system development in the country and gives constructive advices to all levels of the monitoring departments to improve the monitoring system development. References | Related Articles | Metrics

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Evaluation on Methadone Oral Solution Containing High Melocular Weight Povidone by EMA WANG Yu-zhu ,XIAO Hui-lai 2015, 12(5): 279-281.  Abstract ( 280 )   PDF (435KB) ( 175 )   Based on the estimated result that methadone oral solution containing high molecular weight povidone K90 induced more risk of 'povidone storage disease' than benefit, so EMA suspended marketing authorisation of this kind of drugs in European Union since 2014. The paper introduces the EMA's evaluation basis. It is expected to enlighten us on the work such as reevaluation on post-marketing drugs including methadone and the related management measures. References | Related Articles | Metrics

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Application of the Technology of Proteomics in Hepatotoxicity of TCM LI Xiao-yu ,HUANG Na -na ,SUN Rong 2015, 12(5): 282-285.  Abstract ( 335 )   PDF (577KB) ( 307 )   Objective To discuss the latest progress of proteomics technology in hepatotoxicity of traditional Chinese medicine (TCM). Methods References in the last decade at home and abroad about the application of proteomics technology in hepatotoxicity of TCM were collated, analyzed and summarized. Results Compared with traditional toxicology, to xicoproteomics was used to find out the toxic substances more quickly and accurately when classic toxicology, pathology and proteins express analysis technology were integrated into it, which could be applied to the study of biomarkers and drug targets independently and also to the supplement and verification of the mechanism research. Conclusion The knowledge of toxic mechanism of TCM has been raised to a new level due to the application of technology of proteomics, which is a suitable platform for screening toxicity biomarkers, exploring mechanism of toxic effect predicting toxicity and establishing protein databases related to toxic effects, and provides an appropriate technology system for the research of hepatotoxicity assessment, clinical diagnosis and hepatotoxicity mechanism of TCM. References | Related Articles | Metrics

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Reasonable Use of Antihypertensive Drugs in Lactating Women ZHAO Min ,SUN Rui-fang,ZHAO Xue-zeng 2015, 12(5): 286-289.  Abstract ( 398 )   PDF (499KB) ( 385 )   Objective To promote the reasonable use of antihypertensive drugs in lactating women. Methods The commonly used antihypertensive drugs were summerized and evaluatad by referring to related books, literatures and medicine instructions, based on Dr. Hale's Lactation Risk Category and American Academy of Pediatrics Committee on Drugs. Results Nifedine, propranolol, metoprolol, labetalol, captopril, enalapril and hydrochlorothiazide appear safe for use in lactating women. Conclusion Prescribing medications fora breast-feeding mother requires weighing the benefits of medication use for the mother against the risk of not breast-feeding the infant or the potential risk of exposing the infant to medications. The physician should select the safest and most effective medication and make an appropriate therapeutic regimen. References | Related Articles | Metrics

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Literature Analysis of 71 Cases of Hypophosphatemia Osteomalacia Induced by Adefovir Dipivoxil ZHAI Shu-yue ,XIE Yan-jun ,WANG Bing-jie ,XU Li-li ,CUI Xiao-kang ,IAN Yue-jie 2015, 12(5): 290-295.  Abstract ( 449 )   PDF (704KB) ( 127 )   Objective To master hypophosphatemia osteomalacia's clinical characteristics which caused by low-dose adefovir dipivoxil, and find the prevention and treatment measures. Methods By searching the data of Pubmed, Chinese Biomedical Literature Service System and China Category January 1st, 2002~December 31st, 2014, the data of hypophosphatemia reported in cases caused by adefovir was summarized and analyzed. Results A total of 39 relevant documents and one graduate thesis were retrieved, including 71 cases. All of the patients havea history of hepatitis B disease and a long-term use of adefovir dipivoxil.With slow progression of adverse reactions, the main clinical manifestations are skeletal pain. Some patients experienced serious adverse reactions, such as walking disorders and muscle atrophy. Laboratory tests appeared to reduced phosphorus levels and elevated serum alkaline phosphatase activity. Imaging studies showed different degrees of skeletal damage. After being taken to the treatment, the patient's symptoms were eased for varying degrees. Conclusion A long-term low-dose adefovir dipivoxil treatment of chronic hepatitis B may cause phosphorus bone softening disease. Therefore, we need to strengthen the monitoring of clinical medicine, check the phosphorus levels, and imaging examination can be used as an effective means to find hypophos-phatemia bone damage caused by adefovir. If patients had adverse reactions effective treatment should be taken timely. References | Related Articles | Metrics

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Literature Analysis of 44 Cases of Adverse Drug Reactions Induced by Polygeline Injection CHEN Hai-tao ,ZHANG Lin-hong ,ZAN Wang 2015, 12(5): 296-298.  Abstract ( 386 )   PDF (599KB) ( 341 )   Objective Through analyzing adverse drug reaction cases of polygeline injection to explore the regularity and cause of adverse drug reactions, provide reference for clinical rational drug use. Methods By retrieving CNKI database and Wanfang database, 44 cases of polygeline injection ADRs reported from 26 literatures were analyzed. Results Most of the ADRs are immediate response type, 91% cases happened within 30 mins, which involv multiple systems and organs including systemic lesions(62.50%) and cardiovascular lesions(10.94%). Allergic shock and severe anaphylactoid reactions are more obvious. At the same time, new ADRs are found in 44 cases. Conclusion More at tention should be paid to the ADRs of polygeline injection and the monitoring of medication should also be strengthened to ensure the safe medication. References | Related Articles | Metrics

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Literature Review of 38 Adverse Reaction Cases Induced by Compound Tropicamide Eye Drops LI Hong ,HU Jun-min 2015, 12(5): 299-301.  Abstract ( 486 )   PDF (622KB) ( 314 )   Objective Through investigating the characteristics and mechanism of adverse reactions induced by compound tropicamide eye drops, to find its risk factors and provide technical support for safe and rational use of drugs in clinic. Methods Using "compound tropicamide eye drops", "adverse reaction" and "caused by" as key words to retrieve articles in the CNKI database. Nineteen references which met the inclusion and exclusion criteria were extracted and analyzed. Results Children, middle-aged and old patients appear to have higher ADR occurrence rate by using compound tropicamide eye drops. Systems and organs mainly involved in adverse reactions are eye, skin and its appendages, sys temic damage, cardiovascular damage, and etc. An allergic reaction, blepharitis, heart palpitations are the most common reported adverse reactions. Conclusion It is important to pay attention to the adverse reactions caused by compound tropicamide eye drops, specially to strengthen middle-aged and old patients postmarketing surveillance, in order to prevent adverse drug reactions and ensure the safe drug use in clinic. References | Related Articles | Metrics

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Discussion on the Reporting Standards and Quality of Adverse Events in Clinical Researches LI Qing-na ,LU Fang GAO Rui 2015, 12(5): 302-304.  Abstract ( 460 )   PDF (525KB) ( 401 )   Objective To discuss the reporting standards and quality of adverse events (AEs) in clinical researches. Methods The reporting standards of AEs on three occasions were analyzed and the quality requirements of the original data when coding with MedDRA terminology were illustrated. Results Aggravation of researched diseases: the natural course of diseases is not considered as AEs unless it develops intoa new diagnosis. Abnormal results of laboratory examinations: there are three occasions in which abnormal results are regarded as AEs, along with clinical symptoms or signs, the need of implementing medical intervention, clinically significant. Repeating AEs: it is necessary to report another AE once a disappeared or recovered AE happens again. The original data should be clear, concise, complete and accurate if AE terms are coded with MedDRA terminology. Conclusion The standards of AE reporting should be specified in study protocols and conduct trainings before starting a trial in order to unify the reporting standards and improve the quality of original data. References | Related Articles | Metrics

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Investigation of the Efficacy and Safety of Stent Graft Treatment for Abdominal Aortic Aneurysm in China LIU Wei 2015, 12(5): 305-307.  Abstract ( 318 )   PDF (546KB) ( 266 )   Objective To investigate the efficacy and safety of stent graft treatment for abdominal aortic aneurysm in China. Methods Key words such as "abdominal aortic aneurysm" and "endovascular" or "stent" and other words were retrieved from Wangfang database and CNKI VIP database and other domestic periodicals database. Results 9 articles met with the requirements of Chinese literature, the lowest success rate of operation was 91.35%, the majority success rate were close to 100%. The incidence rates of main adverse events were between 1.74%～9.80%, the incidence of endoleak between 4.65%～19.61%, the highest mortality rate of patients in 30 days was 7.89%. Conclusion The efficacy of the stent graft in China applied to treat abdominal aortic aneurysm was relatively certain, but comments regarding the complications of stent graft to treat abdominal aortic aneurysm need more high quality research to verify. References | Related Articles | Metrics

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Comparative Analysis of One-Man and Two-Men Colonoscopy in 1112 Patients CAI Ling ,ZHANG Mei ,ZHAO Qu-chuan 2015, 12(5): 308-310.  Abstract ( 338 )   PDF (674KB) ( 189 )   Objective To compare the clinical application of one-man and two-men colonoscopy. Methods 1 112 patients were separately examined with the technique of one-man and two-men colonoscopy from May 2013 to May 2014. The indicators of the rate of reaching ileocecum, inserting time, colonoscopy length, pain score and polyp rate of missed diagnosis were compared. Results The rates of reaching ileocecum of the routine technique of one-man and two-men colonoscopy were 98.42% and 93.23% respectively. The average inserting times of the two methods were 5.51±3.22 min and 11.54±3.83 min respectively( P<0.05). Colonoscopy lengths of the two methods were 71±17cm and 89±22cm respectively( P<0.05). The pain scores by the NRS questionnaire of the two methods were 2.69 ±1.60 and 6.82±2.14 respectively( P<0.05). Polyp rates of missed diagnosis were 11.82% and 20.13% respectively ( P<0.05). No serious complications were observed in all examinations. Conclusion The technique of one -man colonoscopy has a high success rate. Compared with two-men colonoscopy, one-man colonoscopy has a shorter inserting time, and colonoscopy length, which reduces the patients pain, polyp rate of missed diagnosis and endoscopic loss. References | Related Articles | Metrics

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Expert Investigation Study on Risk Factors of Medication for Children in China LI Rui-xia, WU Zhi-ang 2015, 12(5): 311-313.  Abstract ( 437 )   Objective Through identification, carding and evaluation of the risk factors of medication for children, to put forward the corresponding measures to ensure children's medication safety. Methods Using fishbone diagram method, child risk factors were combed, and then perfected by the method of expert advice consulting. According to expert scoring, the risk factors which are of high importance were concluded by using analytic hierarchy process(AHP) to analyze the result of the score. On the basis of these researches, coping strategies were put forward. Results and Conclusion The risk factors in the two links-physician diagnosis and medication of children are relatively more. The top five important risk factors are as follows: the dosage unit or zero or decimal point is incorrect when doctors prescribe, nurses don't check the information of the children carefully when applying medicine, doctors are unfamiliar with children's physiological and pathological characteristics, doctors ignore the history of disease and allergy in children, and doctors write the name of the similar drug when prescribing. We need to use the following measures to ensure the safety of children's drugs: risk communication, training and continuing education, establishing the memo and the appraisal system, etc. References | Related Articles | Metrics