A Randomized Controlled Clinical Trial of Tongluozhanshitang in Treatment of Erectile Dysfunction Based on Renal Deficiency and Blood Stasis

Abstract

Abstract: Objective To evaluate the clinical therapeutic effect of Tongluozhanshitang in treatment of erectile dysfunction. Methods 62 cases of control group were treated by Fufangxuanju capsule, 58 cases of treatment group were treated by Tongluozhanshitang, both for4 weeks. The international index of erectile function (IIEF-5), score of mend sexual life quality questionnaire (mSLQQ), score of symptoms of Chinese medicine (SSCM) were compared between two groups before and after theatment. Results IIEF-5 and mSLQQ of two groups presented siginificant statistical difference( P<0.01). Treatment group was superior to control group. The total effective rate was 82.7% in treatment group, 72.5% in control group. Conclusion Tongluozhanshitang in the treatment of ED has more obvious effectiveness and improvement of life quality than Fufangxuanju capsule.

Key words: Tongluozhanshitang, erectile dysfunction, renal deficiency and blood stasis

CLC Number:

R965

CHENG Hai-sheng ,ZHANG Tao ,ZHANG Xue-song ,MO Xu-wei ,LI Hai-song. A Randomized Controlled Clinical Trial of Tongluozhanshitang in Treatment of Erectile Dysfunction Based on Renal Deficiency and Blood Stasis[J]. Chinese Journal of Pharmacovigilance, 2015, 12(5): 264-266.

References

[1]郭应禄,胡礼泉.男科学[M].北京:人民卫生出版社,2004:1482-1483.
[2] FeldmanH A, Goldstein I, HatzichristouD G,,et al.Impotence and its medical and psychosocial correlates:results of the Massachusetts male aging study[J].J UROL,1994,151(1):54-61.
[3] RosenR C, Riley A,Wagner G, et al. The International Index of Erectile Function（IIEF）：amultidimensional scale for the assessment of erectile dysfunction[J].Urology,1997,49(6):822-829.
[4] 郑筱萸 .中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:178-179.
[5]吴以岭,络病学[M].北京:中国科学技术出版社，2004:80-112.
[6] 中华中医药学会糖尿病分会.糖尿病勃起功能障碍诊断标准[J].世界中西医结合杂志,2011,6（2）:180.
[7] 蔡建,邓哲献,蔡海波.复方玄驹胶囊治疗勃起功能障碍的疗效观察[J].中华男科学杂志,2006,12（6）：568-569.
[8] 方药中,邓铁涛,李克光,等.实用中医内科学[M].上海科学技术出版社，1997:315-318.
[9]李海松,韩富强,王彬.男科络病初探[J].北京中医药大学学报， 2009,10（32）:719-720.
[10]鲁豫,鲁平,吴刚.初诊 2型糖尿病内皮功能与阴茎深动脉血流动力学关系的研究[J].中国超声医学杂志,2003,19(8):617-620.
[11] Chang S,HypoliteJ A,Changolkar A,et al.Increased contractility of diabetic rabbit corpora smooth muscle in response to endothelin is mediated via Rho-kinase beta[J].Int J impot Res,2003,15(1),53-62.
[12]侯孟君,陈云波,王奇,等.血瘀证兔模型血管内皮细胞中一氧化氮合酶的基因表达及其分泌一氧化氮的变化[J].广州中医药大学学报,2001,18（1）:53-57.
[13]黄敏,谢建祥,吴锐,等.血瘀证目征与血管内皮细胞损伤的关系[J].中华中医药杂志，2011,26（4）:781-784.
[14]李凤文,张立石,刘红,等.水蛭、丹参及其复方对血瘀大鼠血管内皮细胞保护作用的研究[J].中国中医药杂志,2001,26（10）：703-706.
[15]陈利国,屈援,葛红颖,等.补阳还五汤对血瘀证大鼠血管内皮细胞黏附分子表达的影响[J].中草药,2005,36（5）:706-709.
[16]周涛.补肾活血中药对实验性血瘀证大鼠血管内皮细胞功能的影响[J].中华中医院学刊,2007,25（9）:1920-1922.