Literature Analysis of 71 Cases of Hypophosphatemia Osteomalacia Induced by Adefovir Dipivoxil

Abstract

Abstract: Objective To master hypophosphatemia osteomalacia's clinical characteristics which caused by low-dose adefovir dipivoxil, and find the prevention and treatment measures. Methods By searching the data of Pubmed, Chinese Biomedical Literature Service System and China Category January 1st, 2002~December 31st, 2014, the data of hypophosphatemia reported in cases caused by adefovir was summarized and analyzed. Results A total of 39 relevant documents and one graduate thesis were retrieved, including 71 cases. All of the patients havea history of hepatitis B disease and a long-term use of adefovir dipivoxil.With slow progression of adverse reactions, the main clinical manifestations are skeletal pain. Some patients experienced serious adverse reactions, such as walking disorders and muscle atrophy. Laboratory tests appeared to reduced phosphorus levels and elevated serum alkaline phosphatase activity. Imaging studies showed different degrees of skeletal damage. After being taken to the treatment, the patient's symptoms were eased for varying degrees. Conclusion A long-term low-dose adefovir dipivoxil treatment of chronic hepatitis B may cause phosphorus bone softening disease. Therefore, we need to strengthen the monitoring of clinical medicine, check the phosphorus levels, and imaging examination can be used as an effective means to find hypophos-phatemia bone damage caused by adefovir. If patients had adverse reactions effective treatment should be taken timely.

Key words: adefovir dipivoxil, hypophosphatemia, osteomalacia, retrospective analysis

CLC Number:

ZHAI Shu-yue ,XIE Yan-jun ,WANG Bing-jie ,XU Li-li ,CUI Xiao-kang ,IAN Yue-jie. Literature Analysis of 71 Cases of Hypophosphatemia Osteomalacia Induced by Adefovir Dipivoxil[J]. Chinese Journal of Pharmacovigilance, 2015, 12(5): 290-295.

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