Abstract: Objective Through analyzing adverse drug reaction cases of polygeline injection to explore the regularity and cause of adverse drug reactions, provide reference for clinical rational drug use. Methods By retrieving CNKI database and Wanfang database, 44 cases of polygeline injection ADRs reported from 26 literatures were analyzed. Results Most of the ADRs are immediate response type, 91% cases happened within 30 mins, which involv multiple systems and organs including systemic lesions(62.50%) and cardiovascular lesions(10.94%). Allergic shock and severe anaphylactoid reactions are more obvious. At the same time, new ADRs are found in 44 cases. Conclusion More at tention should be paid to the ADRs of polygeline injection and the monitoring of medication should also be strengthened to ensure the safe medication.

Key words: polygeline injection, adverse drug reactions, literature analysis