Application of the Technology of Proteomics in Hepatotoxicity of TCM

Abstract

Abstract: Objective To discuss the latest progress of proteomics technology in hepatotoxicity of traditional Chinese medicine (TCM). Methods References in the last decade at home and abroad about the application of proteomics technology in hepatotoxicity of TCM were collated, analyzed and summarized. Results Compared with traditional toxicology, to xicoproteomics was used to find out the toxic substances more quickly and accurately when classic toxicology, pathology and proteins express analysis technology were integrated into it, which could be applied to the study of biomarkers and drug targets independently and also to the supplement and verification of the mechanism research. Conclusion The knowledge of toxic mechanism of TCM has been raised to a new level due to the application of technology of proteomics, which is a suitable platform for screening toxicity biomarkers, exploring mechanism of toxic effect predicting toxicity and establishing protein databases related to toxic effects, and provides an appropriate technology system for the research of hepatotoxicity assessment, clinical diagnosis and hepatotoxicity mechanism of TCM.

Key words: proteomics, hepatotoxicity of TCM, toxicology

CLC Number:

LI Xiao-yu ,HUANG Na -na ,SUN Rong. Application of the Technology of Proteomics in Hepatotoxicity of TCM[J]. Chinese Journal of Pharmacovigilance, 2015, 12(5): 282-285.

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