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Changes of Liver Function in 35 Patients Orally Taking Polygoin Multiflori Radix Preparations
ZHOU Ming, FEI Zhanyang, ZHAO Jiuli, XUE Dan, LI Ming, LI Dengke, Wang Zijian, LI Yiqun, TANG Xuechun, SUN Zhenxiao
2021, 18(3):
235-239.
DOI: 10.19803/j.1672-8629.2021.03.06
Objective To analyze the post-treatment changes of liver function in patients taking a conventional dosage of decoction and Chinese patent medicine containing Polygoni Multiflori Radix(PMR), and to determine the risk of liver injury in clinical application. Methods The clinical data on 35 cases who used decoction and Chinese patent medicine containing PMR was collected. Their liver function indexes, such as alanine aminotransferase(ALT), aspartate aminotransferase(AST), alkaline phosphatase(ALP),γ-glutamyl transpeptadase (GGT), total bilirubin(TBIL), direct bilirubin(DBIL) and indirect bilirubin(IBIL) , were detected. The patients were divided into two groups according to the normality of their liver function indexes before treatment and the incidence of liver injury after treatment was analyzed. Results There was no significant difference in levels of AST, ALP, GGT, TBIL, DBIL or IBIL after treatment(P>0.05)in patients who had normal liver function before treatment, but there was significant difference in ALT(P<0.05)that was in the normal range. Among patients who had abnormal liver function before treatment, there was also no significant difference in levels of ALP, GGT, TBIL or IBIL after treatment(P>0.05), but some of their liver function indexes decreased after treatment. Conclusion Taking orally a conventional dosage of decoction and Chinese patent medicine containing PMR is relatively safe and has lower clinical risk of liver injury.
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