Literature Analysis of Adverse Drug Reactions Induced by Olanzapine

doi:10.19803/j.1672-8629.2021.03.11

Abstract

Abstract: Objective To investigate the regularity and characteristics of adverse drug reactions (ADR) induced by olanzapine so as to provide reference for safe and rational use of drugs. Methods CNKI, Wanfang and VIP databases were searched for literature related to ADR induced by olanzapine. The included articles were analyzed retrospectively. Results A total of 82 articles involving 104 patients were retrieved. The ratio of males to females was 1∶1.08, and the age of most of these patients ranged from 18 to 44 (51 cases, 49.04%). Thirty-three of these patients (31.73%) had adverse reactions within 2 to 7 days of medication. The dominating systems or organs involved were the central nervous system (56 cases, 29.79%) as manifested by tardive dystonia and restless leg syndrome, followed by metabolic and nutritional disorders (33 cases, 17.55%). Conclusion Adverse reactions induced by olanzapine are worthy of attention. Drug use monitoring has to be strengthened to ensure drug safety.

Key words: olanzapine, adverse drug reaction, literature analysis

CLC Number:

R969

ZHAO Zeqing, WANG Rui, YU Panpan, QIAO Pingping. Literature Analysis of Adverse Drug Reactions Induced by Olanzapine[J]. Chinese Journal of Pharmacovigilance, 2021, 18(3): 260-264.

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