Abstract: Objective To summarize the research progress in clinical application and safety of lithium carbonate used for mania, and to provide reference for clinical rational drug use. Methods Domestic and foreign literature on the clinical application and safety of lithium carbonate was reviewed for analysis and comparison. Results The treatment dose of lithium carbonate is close to the toxic dose, which is likely to cause damage to the nervous system, urinary system, endocrine system, gastrointestinal system, and even lithium poisoning. Lithium carbonate is currently often used in combination with other antipsychotic drugs in the treatment of mania, and the blood lithium concentration has to be detected many times during the treatment to ensure the safety of medication. Conclusion Lithium carbonate remains the first-line drug for the prevention and treatment of mania at home and abroad. It is suggested that the combination of lithium carbonate with other antipsychotics be considered in clinical medication. Attention should be paid to the occurrence of adverse reactions, and the rational use of drugs should be promoted according to the blood lithium concentration and individual differences.

Key words: lithium carbonate, mania, combination therapy, adverse reactions, blood lithium monitoring