One Case of Anaphylaxis Induced by Peg-containing Cyclosporine Injection

doi:10.19803/j.1672-8629.2021.03.14

Abstract

Abstract: Objective To analyze one case of anaphylactic shock caused by cyclosporine injection containing polyethylene glycol (PEG) so as to highlight the need to analyze the potential sensitizing components of the drug. Methods The causes of anaphylactic shock induced by cyclosporine injection during hematopoietic stem cell transplantation in a patient with severe aplastic anemia were analyzed according to the Knoop's score and literature analysis. Results The score was 11, and the "positive" allergic reaction was related to the infusion of cyclosporine injection. Conclusion In case of allergic reaction of drugs containing polyethylene glycol, the causes of allergic reactions need to be analyzed and evaluated with proper evaluation tools. Once the allergic reactions are proved to be related to polyethylene glycol, clinicians should be alert to the possible fatal adverse reactions caused by other drugs containing polyethylene glycol components when they are reused. The adverse reactions should be identified and treated immediately, or other drugs without these ingredients should be used.

Key words: polyethylene glycol (PEG), anaphylaxis, cyclosporine injection, adverse drug reaction

CLC Number:

R994.11

MAO Min, LIAO Mingyan, MAO Jian. One Case of Anaphylaxis Induced by Peg-containing Cyclosporine Injection[J]. Chinese Journal of Pharmacovigilance, 2021, 18(3): 274-276.

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