Abstract: Objective Through analysing 40 anaphylaxis cases by Gugua extractives injection to explore the mechanism and characteristics, providea reference for clinical rational use of drugs. Methods By searching literature in Chinese Journal Full-text Database from 1994 to 2013, 29 anaphylaxis literatures of Gugua extractives injection involving 40 cases were statistically analyzed. Results In the 40 anaphylaxis cases by Gugua extractives injection, the incidence of men was more than women, and anaphylaxis often occurred in aged group. 40 anaphylaxis cases all occured in the medication process, the shortest time was 30s after administration and the longest time was 10d, and the most was found 30 minutes after administration. The major clinical manifestations of anaphylaxis involved many systems and organs, and were complexed and varied, and the cardiovascular system was the first, followed by skin and accessories damage, respiratory system, nervous system, digestive system,and oral system. All cases were found timely, made an immediately withdrawal and symptomatic treatment to get satisfactory outcome, and no death cases were reported. Conclusion The doctors and pharmacists should pay attention to the anaphylaxis caused by Gugua extractives injection, and understand the rules and characteristics,and the clinical care should be strengthened so as to prevent the occurrence of adverse reactions.

Key words: Gugua extractives injection, anaphylaxis, literature analysis