Literature Analysis of 52 Cases of Adverse Drug Reactions Induced by Escitalopram

doi:10.19803/j.1672-8629.2020.09.08

Abstract

Abstract: Objective To understand the occurrence and precautions of escitalopram adverse reactions(ADR). Methods The case reports of ADR in Wanfang database, VIP journal network, CNKI and PubMed were searched by computer. The gender, age, time of occurrence, clinical manifestation and involvement system-organs of ADR were analyzed. Results A total of 51 patients were enrolled in the literature, including 52 patients. The incidence of escitalopram ADR was mainly in female and middle-aged (41~65 years old). ADR occurred several hours to 6 months after administration, mainly involving the circulatory system. The nervous system, digestive system, endocrine system and others, among which most cases were hyponatremia. Conclusion Escitalopram should be used according to the recommended dosage of the instructions, and should not be added at will; medical staff should strengthen the attention, monitoring and reporting of ADR to promote clinical rational drug use.

Key words: escitalopram, adverse drug reactions, clinical case analysis, literature analysis

CLC Number:

R971

LIU Hongming, WANG Jian. Literature Analysis of 52 Cases of Adverse Drug Reactions Induced by Escitalopram[J]. Chinese Journal of Pharmacovigilance, 2020, 17(9): 578-582.

References

[1] 张亚同, 傅得兴. 艾司西酞普兰的药理及临床评价[J]. 中国新药杂志, 2006, 15(22) : 1979-1983.
[2] 汤庆平,赖根祥. 艾司西酞普兰治疗抑郁症疗效观察[J].中国药师,2011,14(6) : 836-837.
[3] Nahshoni E, Weizman A, Shefet D, et al.A case of hyponatremia associated with escitalopram[J].J Clin Psychiatry, 2004,65(12) : 1722.
[4] Covveou JA, Jackson CW.Hyponatremia associated with escita-lopram[J].New Engl J Med, 2007,356(1) : 94-95.
[5] Soysal P, Isik AT.Severe hyponatremia due to escitalopram treatmentin an elderly adult with Alzheimers disease[J].J Am Geriatr Soc, 2014,62(12) : 2462-2463.
[6] Korkmaz S, Korkmaz H.Hypertension induced by escitalopram[J]. Turk Psikiyatri Derg, 2011,22(1) : 61.
[7] Tseng PT, Yu L, Lin YE, et al.Low-dose escitalopram for 2 days associated with corrected QT interval prolongation in a middle-aged woman: a case report and literature review[J].Gen Hosp Psychiatry, 2012,34(2) :210.e13-e15.
[8] 孙振晓, 王相立. 艾司西酞普兰致血小板减少一例[J]. 精神医学杂志, 2013, 26(2):118.
[9] 梅建华. 草酸艾司西酞普兰致抗利尿激素分泌异常综合征2例[J].浙江实用医学,2016, 21(1):74-75.
[10] 高红锐. 草酸艾司西酞普兰致QTC间期延长1例[J].中国民康医学, 2017, 29(13):127.
[11] 王蕾蕾,卞清涛.草酸艾司西酞普兰致血小板升高1例[J].神经疾病与精神卫生,2018,18(4):303-304.
[12] 孙振晓, 孙波. 口服艾司西酞普兰片致血小板减少1例[J].中国药物滥用与防治杂志, 2019,25(1):47-48.
[13] 华先平,吴瑞霞.西酞普兰诱发QT间期延长并尖端扭转性室性心动过速一例[J].中华老年心脑血管病杂志, 2011,13(4):373-374.
[14] Sudha V, Karthik R.Escitalopram induced SIADH in an elderly female: A case study[J].Psychopharmacology Bulletin, 2017, 47(4):64-67.
[15] Raj R, Jacob A, Venkatanarayan A, et al.Severe Symptomatic Hyponatremia Secondary to Escitalopram-Induced SIADH: A Case Report with Literature Review[J].Case Rep Nephrol, 2018,32(2):153-157.
[16] Chen PH.Restless Leg Syndrome Induced by Escitalopram and Lithium Combined With Quetiapine Treatment in Bipolar II Disorder: A Case Report[J]. Clin Neuropharmacol, 2016,39(2):118-119.
[17] Kul M, Kilincaslan A, Yumru M, et al.Escitalopram-associated mania in a child[J].J Child Adolesc Psychopharmacol, 2008,18(1) :119-120.
[18] Lai CH.Escitalopram-Related Visual and Auditory Hallucinationin a Non-Dementia Patient With Depression[J].J Neuropsych Clin Neurosci, 2012,24(4):E19.
[19] Albayrak Y, Karaka U urlu G, Ekinci O, et al. Escitalopram-induced severe akathisia: a case report[J].Prim Care Companion J Clin, 2010,12(6):180-181.
[20] Basu B, Gangopadhyay T, Dutta N, et al.A Case of Akathisia induced by Escitalopram: Case Report & Review of Literature[J].Curr Drug Safety, 2014,9(1) :56-59.
[21] Ak S, Yaucioulu AE.Escitalopram-induced Parkinsonism[J].Gen Hosp Psychiatry, 2013,36(1) :1-2.
[22] Jagtar SN, Ashish A.Acute extrapyramidal syndrome induced by escitalopram: a case report[J].Psychopharmacology, 2014,231(18) :3813-3814.
[23] 刘玉局,薛艳萍,王尉,等.艾司西酞普兰致惊恐发作1例报道[J].临床精神医学杂志,2019,29(2):90.
[24] 任丽平. 艾司西酞普兰致锥体外系反应1例报告[J].中国健康心理学杂志,2017,25(7):997-999.
[25] 钟元园,周行涛.草酸艾司西酞普兰致LASEK术后视觉异常一例[J].中国实用眼科杂志,2013,31(10):1360.
[26] AlQuorain S, Alfaraj S, Alshahrani M. Bilateral acute closed-angle glaucoma associated with the discontinuation of escitalopram: a case report[J].Open Access Emerg Med, 2016,9(8):61-65.
[27] Zelefsky JR, Fine HF.Escitalopram-Induced Uveal Effusions andBilateral Angle Closure Glaucoma[J].Am J Ophthalmol, 2006,141(6): 1144-1147.
[28] 胡杨, 梅丹.草酸艾司西酞普兰诱发严重肝损害[J].药物不良反应杂志,2012,24(5):319-321.
[29] Delval A,Ortiz P.Hepatotoxicity related to escitalopram[J].Med Clin,2008,131(20):798.
[30] 姜赛平,卢晓阳.西酞普兰引起肝功能异常[J].药物不良反应杂志,2011,13(3):193-194.
[31] 汪春运. 艾司西酞普兰引起便血1例[J].临床荟萃,2012,27(16):1443.
[32] Belli H,Aslaner D.Escitalopram related erectile dysfunction and spontaneous ejaculation during micturition[J].West Indian Med J, 2010, 59(6): 715-716.
[33] Aggarwal A, Ravi C.Probable epistaxis associated with escitalopram[J].Progr Neuro Psychopharmacol Biolog, 2010, 34(4): 709-710.
[34] Praharaj SK.Euprolactinemic galactorrhea with escitalopram[J].J Neuropsychiatry Clin Neurosci, 2014, 26(3): E25-E26.
[35] 李作佳. 艾司西酞普兰致老年女性患者泌乳1例[J].临床精神医学杂志, 2014, 24(2):140.
[36] Pathania M, Goel B.A rare adverse drug reaction to escitalopram[J].J Family Med Prim Care, 2018, 7(2): 466-467.
[37] Eker SS, Akkaya C, Ersoy C, et al. Reversible escitalopram-induced hypothyroidism[J].Gen Hosp Psychiatry, 2010,32(5): 55 9.e5-7.
[38] Mazokop EE.Escitalopram-induced subclinical hypothyroidism. a case report[J]. Hormones,2012,11(1):101-103.
[39] Zuccoli ML, Milano G.A Case Report on Escitalopram-Induced Hyperglycaemia in a Diabetic Patient[J]. Int J Psychiatry Med, 2013, 46(2):195-201.
[40] Lewien A, Kranaster L, Hoyer C, et al.Escitalopram-related rhabdomyolysis[J].J Clin Psychopharmacolo,2011,31(2):251-253.
[41] Lecardeur L, Lefebvre A, Meunier-Cussac S.Rhabdomyolysis After Escitalopram Treatment in a Young Adult With Melancholic Depression[J].J Clin Psychopharmacolo,2015,35(1):108-109.
[42] Morcan RJ, Dolenc TJ.Escitalopram-induced progressive cervical dystonia[J]. Psycho Somatics,2014,56(5):572-575.
[43] Trombetta D, Garrett K, Harrison M.Escitalopram-Associated Acute Urinary Retention[J].Consult Pharm,2013,28(10):661-669.
[44] Aggarwal A, Kumar R.Escitalopram induced galactorrhoea: A case report[J].Prog Neuropsychopharmacol Bio Psychiatry, 2010, 34(3):557-558.
[45] Ceylan MF, Durukan I.Pyromania Associated with Escitalopram in a Child[J]. J Child Adol Psychoyharmacol, 2011, 21(4):381-382.
[46] Pitchot W.Hair loss associated with escitalopram but not venlafaxine[J]. Prim Care Companion CNS Disord, 2011,13(4): 110-116.
[47] Hekmatjah J, Tareen K, Tareen RS, et al.Citalopram-Associated Alopecia: A Case Report and Brief Literature Review[J]. Current Drug Safety, 2019, 14(2):167-170.
[48] Yang HM, Lee WK.Escitalopram-induced word finding difficulty[J].Gen Hosp Psychiatry, 2013, 35(1):64-69.
[49] Samson YY, Wing YK.Escitalopram-induced delayed drug rash with deranged liver function: a possible case of drug reaction with eosinophilia and systemic reaction[J]. Hong Kong Med J, 2018, 24(3):311-312.
[50] 刘伟健,郑伟.草酸艾司西酞普兰致皮疹1例[J].四川精神卫生, 2019, 32(1):70-71.
[51] 王霞, 宋成燕. 草酸艾司西酞普兰(百适可)致夜间频繁咳嗽1例[J]. 中外健康文摘, 2014, 11(15):270.
[52] Jessica D, Sherry L.Neonatal Toxicity From Escitalopram Use In Utero : A Case Report[J]. J Pediatr Pharmacol Ther, 2016, 21(6):522-526.
[53] Jawale N, Bhutada A.Antenatal Escitalopram Use and Necrotizing Enterocolitis in a Newborn: A Case Report[J]. J Pediatr Pharmacol Ther, 2016, 21(6):518-521.
[54] 王文茜, 陈晨.艾司西酞普兰不良反应文献分析[J].医药导报, 2018, 37(2):256-260.
[55] Heikkinen T, Ekblad U, Laine K.Transplacental transfer of citalopram, fluoxetine and their primary demethylated metabolites in isolated perfused human placenta[J]. BJOG, 2002, 109(9):1003-1008.
[56] 欧洲药品管理局.欧洲药品管理局认为两类抗抑郁症药不应超适应证用于儿童和青少年[J].中国药物警戒, 2005,2(3):186.