Abstract: Objective To summarize and analyze the adverse reactions(ADR) induced by amiodarone injection from Jan. 2011 to Mar. 2012 at our hospital, and to guide the rational drug use. Methods A retrospective study was conducted on the use and medical records of amiodarone injection(n=396) from Jan. 2011 to Mar. 2012 at our hospital, the adverse reactions of abnormal hepatic function , hypotension and bradycardia needing intervention , Torsade de Pointes which were caused by amiodarone injection were counted and analyzed. Results The incidence of the abnormal hepatic function induced by amiodarone injection was 14.6%, the more total quantity of intravenous amiodarone in 24 hours, the more hepatotoxicity the patients got. There were8 patients with hypotension and 4 with severe bradycardia needing intervention, and there were 2 patients with Torsade de Pointes. Conclusion The incidence of adverse reactions of amiodarone injection is low and it's safe under intensive monitoring.

Key words: amiodarone injection, adverse reactions, abnormal hepatic function