Literature Analysis of 45 Cases of Drug-induced Hyperuricemia

doi:10.19803/j.1672-8629.2020.09.07

Abstract

Abstract: Objective To investigate the types of drugs that cause hyperuricemia and the clinical features so as to provide reference for safe medication and treatment. Methods The CNKI and Wanfang database were searched to retrieve case reports of drug-induced hyperuricemia. The types of drugs responsible and high-risk factors were analyzed. Results A total of 39 case reports involving 45 patients were retrieved. A total of 7 categories (14 kinds) of drugs were involved, including 13 cases related to diuretics (28.89%) and 12 cases related to anti-tuberculosis drugs (26.67%). Hyperuricemia occurred in each age group, with those over 60 years old as the most vulnerable (19 cases, 42.22%). Gout occurred in 32 cases while asymptomatic hyperuricemia occurred in 13 cases. Conclusion Patients taking these drugs, especially the elderly with multiple chronic diseases who have to take long-term and combined multiple drugs, should be alert to drug-induced hyperuricemia, and the blood uric acid level should be monitored regularly to prevent the occurrence of hyperuricemia.

Key words: drug-induced, hyperuricaemia, gout, literature analysis

CLC Number:

R595.3

XU Wanyi, CUI Xiangli. Literature Analysis of 45 Cases of Drug-induced Hyperuricemia[J]. Chinese Journal of Pharmacovigilance, 2020, 17(9): 574-577.

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