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08 January 2010, Volume 7 Issue 1    Next Issue

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The Effect of the Combination of Fosfomycin and Aminoglycosides on the Viable Counts of Pseudomonas Aeruginosa Biofilm in Vitro FAN Yan, WANG Rui 2010, 7(1): 1-3.  Abstract ( 272 )   PDF (250KB) ( 304 )   Objective To study the combination effect of fosfomycin and aminoglycosides on the formation of biofilm of Pseudomonas aeruginosa（PAO1） in vitro. Methods The modified plate culture method was used to establish biofilm model in vitro with which the morphology of PAO1 biofilms were observed by the viable counts after treated with different dosages of fosfomycin and aminoglycosides. Results MTT method showed that the viable counts of bacteria of combination gruops were significantly lower than the non-combination groups （P<0.05）. Conclusions There were obvious differences between combination fosfomycin and aminoglycosides groups and non-combination groups in the formation of PAO1 biofilm. Synergistic action of fosfomycin to aminoglycosides is verified. References | Related Articles | Metrics

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Antagonistic Effect of Dangguibeimukushen Pill on Prostatic Hyperplasia in Mice CHEN Ye, ZHAO Dong, CAI Miao, WEN De-zhong, SUN Jian 2010, 7(1): 4-6.  Abstract ( 170 )   PDF (439KB) ( 215 )   Objective To study the antagonistic effect of Dangguibeimukushen Decoction（DBK） on benign prostatic hyperplasia（BPH） and its possiblemechanism. Methods Experimental prostatic hyperplasia was produced in the mice by testosterone injection.After 14 days of the treatments, the mice were sacrificed for measure-ment of the prostate glandular wet weight, the index of prostate gland（PI）, the pathologic changes of prostate gland by light microscopy and the contents of testosterone and estradiol in the serum. Results The prostate wet weight and PI decreased dose dependently after DBK treatment for 14 days compared with the BPH model group（P <0.05or P <0.01）. DBK reduced the serum testosterone, estradiol contents （P <0.05or P <0.01）. Conclusion DBK has significant antagonistic effect on BPH induced by testosterone propionate in mice, which may involve its regulatory action on the sex hormone balance. References | Related Articles | Metrics

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The Cause and Analysis Method of Suspected Medical Device Adverse Events JIANG Dong-gui, WANG Gang, NUERJIANG·shabukai, LI Lei 2010, 7(1): 7-11.  Abstract ( 369 )   PDF (450KB) ( 1148 )   To draw on the human-computer engineering research Results, sum up and conclude the theoretic classification of damage and the current vast majority causes of suspected medical device adverse incidents, compare the current widespread using of security incidents analysis Methods in the feasibility analysis, we found the analysis modeled from the fault tree is relatively reliable and generally applicable to cause analysis of suspi-cious incident. References | Related Articles | Metrics

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Introduction of Methods in Evidence-based Evaluation of Adverse Drug Reaction LIU Jian-ping, XING Jian-min 2010, 7(1): 12-15.  Abstract ( 341 )   PDF (466KB) ( 610 )   This assay introduce the basic concept of adverse drug reaction and its relevant terms for describing adverse drug reaction, evidence-based pharmacology, the hierarchy of evidence grading for health interventions, the Methods for evaluating the adverse drug reaction, and the principle and Methods of referring causality from clinical data. References | Related Articles | Metrics

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Introduction of International Information and Resources of Adverse Drug Reaction XIA Yun, HAN Mei, LIU Jian-ping 2010, 7(1): 16-19.  Abstract ( 234 )   PDF (690KB) ( 761 )   Since the 20th century, adverse drug reaction has become an important issue for current public health, which needs to be faced and resolved. In this paper, we introduce international and domestic resources on adverse drug reaction including the monitoring agency, internet resources and publications from journals. References | Related Articles | Metrics

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Analysis of Safety Reporting in Clinical Trials on Herbal Medicine Published in Chinese Journals LI Xun, LI Xin-xue, LIU Zhi-jun, MA Li-xin, LIU Jian-ping 2010, 7(1): 20-24.  Abstract ( 208 )   PDF (482KB) ( 228 )   Objective To evaluate the safety reporting in randomized clinical trials（RCT） on Chinese herbal medicine published between 2005 to 2009 and compare with the previous Results to find out whether there is any improve-ment. Methods Searched Journal of Traditional Chinese Medicine, Fujian Journal of Traditional Chinese Medicine and Journal of Chengdu University of Chinese Medicine for all the RCTs on herbal meidicne published in the recent 5 years, extracted data about safety reporting in method, result and discussion. Results In the three journals reviewed, only 37%（204/550）、38%（140/364）and 38%（29/76）respectively reported safety data, which did not demonstrate im-provement compared with the previous data from 15 years （over arching 25 years in total） as 40%（354/879）, 38%（173/452）, and 33%（40/123）, respectively. Conclusion The awareness of safety observation and reporting in herbal trials is still far away from their sufficient reporting. References | Related Articles | Metrics

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Study on Standards and Norms of Drug Safety Monitoring Data and Comprehensive Analysis HUANG Chuan-hai, TIAN Yue-jie, LI Pan-hai, LIU Wei, JIN Shao-hong 2010, 7(1): 25-27.  Abstract ( 187 )   PDF (505KB) ( 394 )   Drug safety monitoring is the basic content of pharmacovigilance.Comprehensive analysis on monitor-ing data which is the most complex and most difficult step, is a key step in pharmacovigilance. No unified standards in the world update. With the analyzed characteristics of drug safety monitoring data through systematic research in China, drawing on international experience, combining with our national conditions, development of drug safety monitoring data, a comprehensive analysis of standards and norms, the standardization of evaluation and analysis were improved effectively, and the result of bias due to human factors is reduced, and contribute to enhancing drug safety analysis of information utilization levels, to improve drug safety monitoring system, and also to reduce the incidence of drug safety and impact. References | Related Articles | Metrics

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The Understanding and Discussion about Conducting Pharmacovigilance in Medical Agencies ZHAO Huai-quan 2010, 7(1): 28-30.  Abstract ( 259 )   PDF (594KB) ( 394 )   By researching the current states of drug use and safety supervision in medical agencies, the important role of pharmacovigilance system on safe, effective and rational use of drugs have been analyzed, and the Methods and contents of pharmacovigilance have been discussed. Some suggestions for developing relevant laws and regulations have been proposed to ensure the pharmacovigilance work. References | Related Articles | Metrics

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Hazards and Protective Measure to Dangerous Medicine for Medical Member JIANG Shan-ling, ZHANG Hua-yun, WU Ling, SUN Ming-qin 2010, 7(1): 31-32.  Abstract ( 266 )   PDF (490KB) ( 279 )   Objective To formulate protective measure, reduce expose risk of danger medicine. Methods Through literature, search according of medical member health destructive of vocational contact for danger medicine expose. It appeal government department and hospital lead, strengthen management of danger medicine expose, install sciencecom-pounding place, construct the system of instruction and training, take utility protective device, and secure medical health. Results Internal, the many hospital have been contructsd vein medicine collocation center with training professional staff disposed dangerous medicine to decrease chance of dangerous medicine expose. Conclusion My popliteal medical member cytotoxic drug protection are not enouge and precau-tion consciousness are frail. It should pay more attention formulate and implement effectual protective device to secure the occupation of medical member. References | Related Articles | Metrics

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Safe Medication in Digital Hospital XU Hou-ming 2010, 7(1): 33-36.  Abstract ( 206 )   PDF (557KB) ( 248 )   Safe medication is more and more attention by man. Some hospitals have developed much software for prescriptions, adverse drug reactions and the rational use of antibiotics based on information systems. In digital hospital, we should make full use of information technology, integration of information resources, using the theory of cross-disciplinary excavation, analysis and evaluation of information and utilization; improving the level of medication to en-sure the safety medication. References | Related Articles | Metrics

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Research Development on Toxicity of Rhizoma Pinelliae Related to Efficacy and Chemical Material Basis SUN Rong, HUANG Wei, BAO Zhi-ye, LV Li-li 2010, 7(1): 37-40.  Abstract ( 270 )   PDF (565KB) ( 557 )   Objective To provide literature evidences asis and research ideas of efficacy and toxicity of the chemical composition of guided separation,control and efficacy, and the research on the“dose-effect relationship” and “dose-toxicity relationship” about the toxicial components. Methods References in the last decades both at home and abroad about Rhizoma Pinelliae were collated, analyzed and summarized. Results The research on Rhizoma Pinelliae about the toxicial effects based on the efficacy and the material basis are confined to single disciplines. Between and even mutual relevance studies are very lack of. Conclusion The research on Rhizoma Pinelliae about the toxicity and margin of safety control based on the chemical separation and quality control about the effective material basis combined with the process of the effectiveness of expression, so as to provide consummating safety standards and putting forward early-warning scheme of adverse reaction, the early diagnosis and treatment measures that can be referred to clinical usage. Rhizoma Pinellia will be ensured to use safety as a clinical drug. References | Related Articles | Metrics

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Adverse Drug Reaction Automatic Monitoring Techniques WANG Yuan-hang, LIU Gui-yang 2010, 7(1): 41-44.  Abstract ( 294 )   PDF (647KB) ( 218 )   Objective To review adverse drug reaction automatic monitoring Methods which based on computer network technology and intelligent recognition technology. Methods The researches in this field published in recent years were collected. All these researches were set up different groups and analyzed by literature research method. Results Commonly used Methods include "triggers" technology and "free-text information extraction" technology, in which the "trigger" technology was further studied by several teams, while the " free-text in-formation extraction" technology still had some key issues to be resolved. Conclusion Using computer software could automatically monitor the patients with the occurrence of adverse drug reactions. Application of this technology could compensate the shortcomings for omitting the current high rate of self-reporting techniques and time-poor. It was a kind of new technology which had a broad application prospects. References | Related Articles | Metrics

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Analysis of Rare Side-effect of Clozapine XU Zuo-guo, ZHANG Shao-dong, SONG Yu-fen 2010, 7(1): 45-47.  Abstract ( 227 )   PDF (597KB) ( 283 )   Objectve The Purpose is to explore are Side-effect of Clozapine. Methods It analyzed the reports on side-effect of clozapine from three kinds journal of psychiatry. Results The study has been found that the new side-effect of clozapine is extrapyramidol, nervous system, respiration system, allergic and withdrawal reaction. Conclusion The Side-effect of Clozapine is the most and severe in antipsychotics and that must be careffuly used in clinical. References | Related Articles | Metrics

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Retrospective Analysis of 178 Traditional Chinese Medicine ADR/ADE Reports LIU Yang, ZHU Bei, GUO Gui-ming 2010, 7(1): 48-51.  Abstract ( 367 )   PDF (727KB) ( 331 )   Objective Analyzed serious adverse drug reaction/event（ADR/ADE） of traditional Chinese medicine（TCM） occurred in our hospital and discuss the related factors of ADR/ADE. Methods 178 ADR reports of TCM collected by our hospital from JUN.2006 to AUG.2008 were analyzed using retrospective study method. Results Amo-ng the 178 ADR/ADE reports, 105 kinds of drugs were involved in different dosage forms and specifications, 96（53.93%） ADR reports were happened in one hour. skin and its adjunct is likely to be the most affected organ. the top three of occurrence frequency in ADR/ADE were injections; and the reports of new ADR/ADE caused by Chi-nese patent medicine is 99（55.62%）. 11 severe adverse reactions were occurred, and oral drugs accounted for a higher proportion.Conclusion ADR monitoring should be strengthened to improve the rational use of drug. References | Related Articles | Metrics

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Analysis of 32 Adverse Drug Reaction Cases Induced by Initravenous Infusion of Azithromyci WEI Jin-xiu, ZHANG Hong-yun, CUI Xiang-li, ZHAO Zhi-gang, BAI Dong-yu 2010, 7(1): 52-54.  Abstract ( 205 )   PDF (577KB) ( 305 )   Objective By analyzing 32 adverse drug reaction(ADR) cases induced by azithromycin introvenous infusion in our hospital, to discuss the rule and clinical feature of ADR induced by azithromycin intravenous, so as to warn the physicists to detect its ADR and prevent the happening of serious incidents. Methods Classify, describe and analyze 32 adverse drug reaction cases induced by initravenous infusion of azithromycin. Results The most constant ADR induced by azithromycin is gastrointestinal and allegic reaction, and it can also induce serious ADR, such as allergic shock and damage of circulatory system. Conclusion Rational use of azithromycin can reduce ADR induced by azithromycin. References | Related Articles | Metrics

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Literature Analysis of 59 Adverse Drug Reaction Reports of Shengmai Injection ZHANG Wen-xia, ZHONG Xi-wen, ZENG Cong-yan 2010, 7(1): 55-58.  Abstract ( 215 )   PDF (725KB) ( 262 )   Objective To explore the general pattern and characteristics of adverse drug reactions(ADR) induced by Shengmai injection so as to provide references for clinical rational use of drug. Methods ADR of Shengmai Injection in 59 case, reported in domestic medical journals from 1994~2008, were collected and analyzed. Results the ADR of Shengmai injection were independent of patient's age and denpendent of patient's sex, male patient were more than female patient. The onset of ADR was usually within 30min after injection. ADR could involve in multiple organs and systems, and clinical manifestations were various, mainly were allergic reaction. Severe allergic reaction could result in anaphylactic shock. Conclusion Doctors and pharmacists should know the pattern and characteristics of ADR, and the use of Shengmai injection should be under strict monitoring to reduce the occurrence of serious ADR. References | Related Articles | Metrics