Abstract: Objective To study the antagonistic effect of Dangguibeimukushen Decoction（DBK） on benign prostatic hyperplasia（BPH） and its possiblemechanism. Methods Experimental prostatic hyperplasia was produced in the mice by testosterone injection.After 14 days of the treatments, the mice were sacrificed for measure-ment of the prostate glandular wet weight, the index of prostate gland（PI）, the pathologic changes of prostate gland by light microscopy and the contents of testosterone and estradiol in the serum. Results The prostate wet weight and PI decreased dose dependently after DBK treatment for 14 days compared with the BPH model group（P <0.05or P <0.01）. DBK reduced the serum testosterone, estradiol contents （P <0.05or P <0.01）. Conclusion DBK has significant antagonistic effect on BPH induced by testosterone propionate in mice, which may involve its regulatory action on the sex hormone balance.

Key words: Dangguibeimukushen pill, benign prostatic hyperplasia, mice