Determination of Chlorogenic Acid in Fufang Shengdi Mixture by HPLC

Abstract

Abstract: Objective To establish a HPLC method for the determination of chlorogenic acid in Fufang Shengdi mixture. Methods A SHISEIDO MG C18 column(250 mm×4.6 mm, 5μm) was used with the mobile phase of 0.4% phosphoric acid and acetonitrile for isocratic elution (10:90) at the wavelength of 327 nm, with the flow rate of 1mL·min-1 and the column temperature was 30℃. Results The calibration curves for chlorogenic acid were linear in the concentration ranges of 0.0624～4.68 μg, and the correlation coefficient was 0.999999. The average recovery was 100.7%,(RSD=1.7%,n=6). Conclusion This method is simple and reproducible,and is suitable for the quality control of the Fufang Shengdi mixture.

Key words: high pressure liquid chromatography(HPLC), Fufang Shengdi mixture, chlorogenic acid

CLC Number:

R917

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XU Wei-ying, ZHENG Xin-ying, GU Xiao-ying, REN Shi-he. Determination of Chlorogenic Acid in Fufang Shengdi Mixture by HPLC[J]. Chinese Journal of Pharmacovigilance, 2014, 11(11): 661-663.

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Determination of Chlorogenic Acid in Fufang Shengdi Mixture by HPLC

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[1]	JIA Yinyin, ZHANG Caishu, ZHOU Ying, LIU Li, GENG Ying, WEI Ningyi, NIU Sijing, CHEN Hua, XU Hui. Evaluation methods for aerodynamic particle size distribution of fine particles in inhaled products [J]. Chinese Journal of Pharmacovigilance, 2024, 21(2): 141-146.
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[3]	WANG Jiaqing, WANG Qi, ZHANG Dongjie, MEI Shenghui, NING Xiao. Uncertainty evaluation on the determination of norvancomycin in human cerebrospinal fluid by UPLC-MS/MS [J]. Chinese Journal of Pharmacovigilance, 2023, 20(12): 1346-1350.
[4]	TAN Liyuan, CAI Tong, WANG Yan. Research progress in quantitative analysis methods for chemical reference substances [J]. Chinese Journal of Pharmacovigilance, 2023, 20(11): 1209-1216.
[5]	ZHONG Yingying, WANG Zhao, ZUO Tiantian, LI Yaolei, LI Hailiang, MA Shuangcheng. Research progress on detection and risk assessment of exogenous heavy metals and related elements in Codonopsis Radix [J]. Chinese Journal of Pharmacovigilance, 2023, 20(11): 1309-1315.
[6]	PANG Yu, LIU Bo, LYU Shaoli, WANG Tao, XING Ying, QIN Xingyu, TIAN Yuejie, WU Wenyu. Exploring the significance of collecting patient reports based on international pharmacovigilance experience [J]. Chinese Journal of Pharmacovigilance, 2023, 20(9): 978-981.
[7]	LIU Yuanxi, GU Donglin, WANG Qi, YAO Lingwen, WANG Ying, JIN Hongyu, MA Shuangcheng. Determination of 87 types of pesticide residues in Polygoni Multiflori Radix by LC-MS/MS [J]. Chinese Journal of Pharmacovigilance, 2023, 20(6): 601-608.
[8]	LI Yanyi, WEN Hairuo, WANG Ying, YANG Jianbo, LIU Yue, WANG Qi, ZHANG Yujie, MA Shuangcheng. Influences of continuous steaming with black bean decoction on contents of 24 components of Polygoni Multiflori Radix [J]. Chinese Journal of Pharmacovigilance, 2023, 20(6): 609-615.
[9]	LAN Jie, WEN Hairuo, HUANG Zhiying, WANG Qi, MA Shuangcheng. Cytotoxicity of HK-2 induced by anthraquinones components of Polygonum multiflorum [J]. Chinese Journal of Pharmacovigilance, 2023, 20(6): 616-622.
[10]	LIU Jingjing, DAI Zhong, YANG Jianbo, WANG Ying, XU Beilei, LIU Yue, WANG Qi, MA Shuangcheng. Spectrum-fect relationship of Ginseng Radix et Rhizoma Rubra and Polygonum Multiflorum Radix Preparata medicinal pair in protection of nerve cells [J]. Chinese Journal of Pharmacovigilance, 2023, 20(6): 623-628.
[11]	LIU Jingjing, XU Beilei, YANG Jianbo, WANG Ying, LIU Yue, WANG Qi, MA Shuangcheng. HT22 Cell and Caenorhabditis elegans models of the anti-aging effect of Ginseng Radix et Rhizoma Rubra and Polygonum Multiflorum Radix preparata medicinal pair [J]. Chinese Journal of Pharmacovigilance, 2023, 20(6): 629-633.
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[14]	ZHOU Yuanhua, WU Liangyong, ZHANG Liwen, DONG Shunling, YAO Shangchen, XU Mingzhe, ZHANG Xianhua. Determination of bactericidal sodium benzoate and potassium sorbate in pediatric oral liquid preparations by HPLC [J]. Chinese Journal of Pharmacovigilance, 2023, 20(4): 365-369.
[15]	LIU Chunliang, LIU Xiaoqiong, ZHANG Lei, ZHU Kexu, CAO Jieyong, WANG Chen, XU Mingzhe, ZHANG Xianhua. Determination of ethylene oxide genotoxic impurity in metoprolol succinate [J]. Chinese Journal of Pharmacovigilance, 2023, 20(4): 370-373.