Chinese Journal of Pharmacovigilance ›› 2011, Vol. 8 ›› Issue (5): 260-262.

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The Effects of Long Cao Particles on the Expression of ET and NO in Hypertensive Rats' Vessels

DONG Gui-ying1, LI Quan-hong1, ZHANG Wei-dong2, WANG Zhao-ming2, SUN Yu2, JIANG Ning1, QIN Ying1   

  1. 1. Jinan Chinese Medicine Hospital, Shandong Jinan 250012, China;
    2. Basic Medical Research Institute of Shandong Medical Academy, Shandong Jinan 250001, China
  • Received:2015-08-27 Revised:2015-08-27 Online:2011-05-10 Published:2015-08-27

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Abstract: Objective To observe the effects of Long Cao Particles on the expression of ET and NO in hypertensive rats' vessels. Methods Divide the spontaneously hypertensive rats(SHR) into such groups as positive, large dose of Long Cao Particles, small dose of Long Cao Particles, negative and wistar. After a month of intragastric administration, test the expression of ET and NO in the vessels by means of immune tissue S-P chemotherapy and hybridization in situ. Results Long Cao Particles can reduce ET and raise the expression of NO in hypertensive rats' vessels. Conclusion By regulating the expression of ET and NO level in vessels, Long Cao Particles can improve the endothelial function and bring high blood pressure down.

Key words: Long Cao Particles, hypertension, ET, NO

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