Abstract: Objective To explore the correlations between the plasma concentrations of risperidone and the contents of serum trace elements in patients with schizophrenia. Methods Two hundred schizophrenia patients who were hospitalized in 2023 and used risperidone alone were selected as the subjects, whose risperidone blood concentrations were detected and divided into low (<20 ng·mL^-1, 17), normal (20~60 ng·mL^-1, 153) and high concentration groups (>60 ng·mL^-1, 30). The contents of such serum trace elements as iron, zinc, copper, manganese and selenium were compared between the three groups while the correlations between blood drug concentrations and the contents of serum trace elements were analyzed. Results ① There was no significant difference in the contents of iron, zinc, copper, manganese and selenium between the normal concentration group and the low concentration group (p>0.05). Compared with the low concentration and normal concentration groups, the contents of iron and zinc were lower while that of selenium was higher in the high concentration group, and the difference was statistically significant (p<0.05).② The proportion of abnormal contents of iron and selenium in the high-concentration group was higher than in the low and concentration groups (p<0.05).③ The plasma concentration of risperidone was negatively correlated with the content of iron, positively with that of selenium, but had no correlations with other trace elements. Conclusion The plasma concentration of risperidone is correlated with the contents of such serum trace elements as iron and selenium. The risk of abnormal iron, zinc and selenium increases with the plasma concentration of risperidone. It is recommended that clinicians monitor the plasma concentration and contents of iron, zinc and selenium.

Key words: Risperidone, Serum Concentration, Trace Elements, Iron, Selenium, Zinc, Schizophrenia, Correlation