Abstract: Objective To analyze a case of hyperprolactinemia caused by the use of risperidone, so as to provide reference for clinical safety and rational medication. Methods In a case of hyperprolactinemia caused on by risperidone use, individualized treatment plan adjustment, pharmacological monitoring, and medication education were carried out, and relevant literature was combined to summarize the clinical manifestations, mechanisms, adverse outcomes, treatment plans, and key points of pharmaceutical monitoring of hyperprolactinemia. Results This case is a patient with severe depressive episodes accompanied by psychotic symptoms. The patient suffered lactation, menstrual problems, and elevated serum prolactin levels on the 17th day of therapy with risperidone for mental illness; however, with the combination of aripiprazole treatment, the patient’s serum prolactin level gradually decreases and the nipple discharge disappears. Conclusion The adverse reaction of hyperprolactinemia caused by antipsychotic drugs have a sense of shame and concealment. During medication, patient monitoring and medication education should be strengthened, and serum prolactin levels should be regularly checked to achieve early identification and adjustment of treatment plans.

Key words: risperidone, aripiprazole, hyperprolactinemia, adverse drug reaction, clinical pharmacist, pharmaceutical monitoring