808 Cases of Adverse Drug Reaction Caused by Antipsychotic Drugs

doi:10.19803/j.1672-8629.20240337

Abstract

Abstract: Objective To analyze the characteristics, patterns, and influencing factors of adverse drug reactions (ADR) caused by antipsychotic drugs, and to provide data for clinical rational drug use. Methods A total of 808 reports about ADR caused by antipsychotic drugs reported by Anhui Mental Health Center Hospital to the National Adverse Drug Reaction Monitoring System between 2022 to and 2023 were collected. The Pareto chart was used to analyze the age of the patients, distribution of types of drugs, time of occurrence, and the major organs/systems involved. Results Among the 808 cases of ADR caused by antipsychotic drugs, the ratio of males to females was 1.3:1, and the incidence was high in groups ages 20-29, 30-39, and 10-19, accounting for 27.97%, 22.40%, and 17.20%, respectively. The reports of ADR involved a total of 15 antipsychotic drugs, with the top 5 drugs as risperidone (20.42%), olanzapine (20.17%), quetiapine (13.49%), aripiprazole (13.24%), and clozapine (13.24%). The main route of administration that caused ADR was oral administration (95.79%). ADR occurred most frequently within 2 to 10 days (37.62%). Neurological damage (46.78%) was the dominating ADR among the organs/systems affected. Among the 808 reports of ADR, there were 728 cases (90.10%) of mild ADR and 80 cases (9.90%) of severe ADR. Most adverse reactions had a good prognosis after symptomatic treatment. Conclusion According to Pareto chart analysis, the age of patients, onset time, and drug types should be considered in case of ADR caused by antipsychotic drugs. It is critical to promptly detect risk signals of drug use and take effective intervention measures to ensure patients' safety.

Key words: Antipsychotic Drugs, Risperidone, Olanzapine, Quetiapine, Aripiprazole, Clozapine, Pareto Chart, Adverse Drug Reaction

CLC Number:

R994.11
R971

DAI Biao, CAO Yin, SUN Yanhong, ZHANG Yuanyuan, XIA Qingrong. 808 Cases of Adverse Drug Reaction Caused by Antipsychotic Drugs[J]. Chinese Journal of Pharmacovigilance, 2025, 22(1): 99-103.

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References

[1] HE JH, WANG WH, HUANG WL, et al.Analysis of Intervention on Irrational Medical Orders in a Psychiatric Hospital[J]. Evaluation and Analysis of Drug-use In Hospitals of China(中国医院用药评价与分析), 2023, 23(2): 250-252, 256.
[2] LIU SY, WANG ZQ.Effects of Centralized Drug Procurement on the Use of Antipsychotics in the Affiliated Brain Hospital of Nanjing Medical University[J]. Drugs and Clinic(现代药物与临床), 2022, 37(6): 1365-1371.
[3] PEI KL, WU YQ, LI Y, et al.Research Status of Aripiprazole in the Treatment of Female Schizophrenia[J]. Chinese Journal of Clinical Pharmacology(中国临床药理学杂志), 2022, 38(15): 1827-1830, 1840.
[4] SHAO Q, ZHANG XH, QUAN W, et al.Retrospective Analysis of Adverse Drug Reaction Induced by Antipsychotics Drug[J]. China Medical Herald(中国医药导报), 2021, 18(14): 156-159.
[5] LYU QY, WANG CZ, XIAO XD, et al.Current Status of Research on Pharmacological Mechanisms and Treatment of Dopamine Hypersensitivity Psychosis[J]. Journal of Neuroscience and Mental Health(神经疾病与精神卫生), 2022, 22(10): 725-729.
[6] SHENG X, YE MQ, TONG JC, et al.Analysis of 1916 Cases of Psychiatry Adverse drug Reaction/Events Reporting[J]. Chinese Journal of Drug Evaluation(中国药物评价), 2017, 34(4): 305-308.
[7] LYU N, YANG S, TIAN H, et al.Pareto analysis of 436 ADR Cases in our Hospital[J]. Chinese Journal of Medicinal Guide(中国医药导刊), 2021, 23(11): 843-847.
[8] LIU JH.Efficacy analysis of Low-Frequency Repetitive Transcranial Magnetic Stimulation and Modified Electric Convulsive Therapy in Patients With Schizophrenia[J]. Chinese Journal of Modern Drug Application(中国现代药物应用), 2023, 17(23): 42-45.
[9] MAO WX, WANG Y, DENG L, et al.Analysis of 1755 Cases of Adverse Drug Reactions of Antipsychotic Drugs in Chongqing[J]. China Pharmaceuticals(中国药业), 2023, 32(19): 13-16.
[10] ZHANG L, QIAN QH, SONG JH, et al.Analysis of 160 Cases of Adverse Drug reaction/Event of Used Anti-Neurosis Medicine With Inpatients[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2011, 8(3): 180-182.
[11] YUAN W, YANG T, SONG Y, et al.Research Progress on Burden and Etiological Mechanism of Mental Health as the Core Comorbidity in Children and Adolescents[J]. Chinese Journal of School Health(中国学校卫生), 2023, 44(9): 1423-1427.
[12] ZHENG HY.A Retrospective Study of Changes in Major Psychiatric Disorders in Pediatric and Adolescent Inpatients From 2001-2022[D]. Anhui: Anhui Medical University, 2023.
[13] ZHOU LH, JIANG WQ, LI HF, et al.Research Progress on the Effect of Common Antipsychotics on Serum Prolactin Levels in Child and Adolescents[J]. Journal of Neuroscience and Mental Health(神经疾病与精神卫生), 2023, 23(9): 650-654.
[14] LIU WSB.Clinical Study of Personalized Drug Therapy for Schizophrenia Based on Gene Detection[D]. Inner Mongolia: Inner Mongolia Medical University, 2022.
[15] CAO LS, WANG JS, ZHANG F, et al.Adverse Drug Reactions Caused by Antipsychotic Drugs in 631 Cases[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2022, 19(3): 322-324.
[16] OH SH, BYEON SJ, CHUNG SJ.Characteristics of Adverse Reactions Among Antipsychotic Drugs using The Korean Adverse Event Reporting System database from 2010 to 2019[J]. Journal of Psychopharmacology, 2022, 36(9): 1041-1050.
[17] XIA WL.Investigation on the Current Situation of Schizophrenia Patients Complicated With Metabolic Syndrome and Study on Related Risk Factors[D]. Wannan: Wannan Medical College, 2023.
[18] WANG ZB, LI RR.Mechanism of Action, Risk Factors, Clinical Characteristics and Treatment Strategies of Antipsychotic-induced Hyperprolactinemia[J]. Chinese Journal of Drug Abuse Prevention and Treatment(中国药物滥用防治杂志), 2024, 30(2): 189-194.
[19] CAO LS, WANG JS, ZHANG F, et al.Analysis of 260 Cases of Adverse Drugs Reactions to Risperidone[J]. Chinese Journal of Clinical Rational Drug Use(临床合理用药), 2023, 16(26): 41-44, 48.
[20] LEUNG JYT, BARR AM, PROCYSHYN RM, et al.Cardiovascular Side-effects of Antipsychotic Drugs: the Role of the Autonomic Nervous System[J]. Pharmacology and Therapeutics, 2012, 135(2): 113-122.
[21] ZHENG SX, ZHENG CJ, WANG CM, et al.Establishment and Application of Medication Therapy Management Model for Patients With Schizophrenia[J]. China Pharmacist(中国药师), 2021, 24(8): 505-508.
[22] ZENG HS, ZHONG CN, ZHONG YL, et al.Analysis of 129 Cases of Adverse Reactions and Clinical Application of Plasma Concentration Monitoring of Olanzapine[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2020, 17(11): 818-822.