Research progress in traditional Chinese medicines against multidrug-resistant Pseudomonas aeruginosa pneumonia

doi:10.19803/j.1672-8629.20220328

Abstract

Abstract: Objective To study the research progress in traditional Chinese medicines against multidrug-resistant Pseudomonas aeruginosa pneumonia and to provide reference for prevention and treatment of Pseudomonas aeruginosa pneumonia infections. Methods Domestic and foreign literature was consulted. The role of TCMs in regulation of bacterial drug resistance, the quorum sensing system, and host microenvironments was reviewed. Results Compared with antibiotics that directly target bacteria, traditional Chinese medicines were characterized by extensive sources, multiple components, multiple targets, and less resistance to drugs, which was of great value for treating multidrug-resistant Pseudomonas aeruginosa pneumonia. Traditional Chinese medicines can play a role in treating anti-bacterial pneumonia by inhibiting the expressions of inactivated enzymes, inhibiting bacterial efflux, regulating the quorum sensing system, improving the host innate immune barrier, and regulating the immune microenvironment. Conclusion It is of great significance to explore the treasure house of TCMs and develop new drugs that are effective against multidrug-resistant Pseudomonas aeruginosa pneumonia in the future.

Key words: traditional Chinese medicine, multidrug-resistant Pseudomonas aeruginosa, pneumonia, host microenvironment, quorum sensing system

CLC Number:

R978

XU Yingli, PANG Bo, CAO Shan, CHEN Mengping, SUN Jing, ZHAO Ronghua, ZHANG Jingsheng, ZHOU Lirun, WANG Yaxin, CUI Xiaolan. Research progress in traditional Chinese medicines against multidrug-resistant Pseudomonas aeruginosa pneumonia[J]. Chinese Journal of Pharmacovigilance, 2023, 20(1): 57-60.

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